952059-61-9

Upstream product

• 952059-64-2 6-methoxy-1,7-naphthyridin-4(1H)-one 
• 1018812-95-7 tert-butyl N-(4-acetyl-6-methoxypyridin-3-yl)carbamate 
• 34392-85-3 3-amino-2-chloro-6-methoxypyridine 
• 952059-62-0 5-[[(2-chloro-6-methoxypyridin-3-yl)amino]methylidene]-2,2-dimethyl-1,3-dioxane-4,6-dione 
• 952059-63-1 8-chloro-6-methoxy-1H-1,7-naphthyridin-4-one 
• 38533-61-8 2-chloro-6-methoxy-3-nitropyridine 
• 183741-80-2 tert-butyl N-(6-methoxypyridin-3-yl)carbamate 
• 6628-77-9 6-methoxy-pyridin-3-ylamine 

Relevant academic research and scientific papers

COMPOUNDS AND METHODS OF USE

The present disclosure relates generally to compounds and pharmaceutical compositions suitable as modulators of protein kinases, and methods for their use in treating disorders mediated, at least in part by, protein kinases.

Discovery of a novel series of thienopyrimidine as highly potent and selective PI3K inhibitors

Inhibition of the phosphoinositide 3-kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) signaling pathway provides a promising new approach for cancer therapy. Through a rational design, a novel series of thienopyrimidine was discovered as highly pote

NAPHTHYRIDINE DERIVATIVES

The invention concerns naphthyridine derivatives of Formula (Ia) or (Ib) or a pharmaceutically-acceptable salt thereof, wherein each of X1, p, R1, G1, G2, q, R2, R3, R4, R5, Ring A, r and R6 has any of the meanings defined hereinbefore in the description; pharmaceutical compositions containing them and their use in the treatment of cell proliferative disorders or disease states associated with angiogenesis and/or vascular permeability.