344-61-6Relevant academic research and scientific papers
Synthesis of 1,2-dihydropyridines using vinyloxiranes as masked dienolates in imino-aldol reactions
Brunner, Bernhard,Stogaitis, Nicole,Lautens, Mark
, p. 3473 - 3476 (2007/10/03)
The application of vinyloxiranes, substituted with an electron-withdrawing group, as masked dienolates in vinylogous imino-aldol reactions was achieved. Under the reaction conditions highly substituted 1,2-dihydropyridines were obtained in moderate to good yields. Mechanistic studies indicate that the reaction proceeds via the formation of an (E)-amino-α,β-unsaturated aldehyde, followed by isomerization to the (Z)-isomer, cyclization, and elimination of a water molecule, leading to the formation of the 1,2-dihydropyridine.
SYNTHESE VON FLUORIERTEN N-ARYLAMINO-ARYLMETHANPHOSPHONSAEUREDIALKYLESTERN
Gruss, Ulrike,Haegele, Gerhard
, p. 209 - 222 (2007/10/02)
Fluorinated α-C- and N-arylsubstituted aminomethanephosphonic acid diethylesters 5 are prepared in high yields by a "two-step" procedure: mixing equimolar amounts of fluorinated benzaldehydes 1 and anilines 2 to benzaldehyde-(N-aryl-)imines 3.Subsequently
