344579-23-3

Basic information

• Product Name: 2-<3-(Methoxycarbonyl)-1-phenylspiro<2.5>oct-1-yl>propandisaeure-dimethylester
• CAS NO: 344579-23-3
• Molecular Weight: 374.434
• Mol File: 344579-23-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-<3-(Methoxycarbonyl)-1-phenylspiro<2.5>oct-1-yl>propandisaeure-dimethylester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-<3-(Methoxycarbonyl)-1-phenylspiro<2.5>oct-1-yl>propandisaeure-dimethylester(344579-23-3)
• EPA Substance Registry System: 2-<3-(Methoxycarbonyl)-1-phenylspiro<2.5>oct-1-yl>propandisaeure-dimethylester(344579-23-3)

Safety Data

• Hazardous Substances Data: 344579-23-3(Hazardous Substances Data)

Upstream product

• 87957-51-5 1-Chlor-t-2-phenylspiro<2.5>octan-r-1-carbonsaeure 
• 87957-61-7 1-Chlor-t-2-phenylspiro<2,5>octan-r-1-carbonsaeure-tert-butylester 
• 87957-43-5 1,1-Dichlor-2-phenylspiro<2.5>octan 
• 100-52-7 benzaldehyde 
• 1608-31-7 (cyclohexylidenemethyl)benzene 
• 67-56-1 methanol 
• 87957-68-4 2-Phenylspiro<2.5>oct-1-en-1-carbonsaeure-tert-butylester 
• 108-59-8 malonic acid dimethyl ester 

Downstream Products

• 87958-01-8 3-Cyclohexyl-2-phenyl-2-propen-1,1,3-tricarbonsaeure-trimethylester 

Relevant articles and documents

Synthesis and Addition Reactions of 2-Phenyl-1-cyclopropene-1-carboxylates

From the olefins 1, 2, and 4 - 7 the 1-chloro-1-cyclopropanecarboxylic acids 15 - 20 are prepareded via the dichlorocyclopropanes 8, 9, and 11 - 14.The trans-isomers 15a - 20a were readily separated.Spiropentane 10 undergoes anionic ring cleavage with BuLi to give finally the ester 33.The tert-butyl esters 21 - 26 yield with KOtBu the cyclopropene esters 27 - 32.The trans-esters 21a - 26a react much faster than the cis-esters b.At C-3 unsubstituted chlorocyclopropane esters, e.g. 34, do not give stable cyclopropene esters even with lithium dialkylamides.Diazomethane adds to the esters 27 - 32 to give the pyrazolines 38 - 43, their isomers a and b being separable.With traces of base the bicyclic pyrazolines are cleaved to 1,4-dihydropyridazines 44 - 46.Cyclopropenes 27 - 30 react with thiophenolate to form the isomeric products 47 - 50; malonate adds to 28 and 31 to give 51, 52.With malononitrile via subsequent reactions the cyclopentadienes 55 - 57 are obtained.