34487-37-1Relevant academic research and scientific papers
Design, synthesis, and testing of an 6-O-linked series of benzimidazole based inhibitors of CDK5/p25
Jain, Prashi,Flaherty, Patrick T.,Yi, Shuyan,Chopra, Ishveen,Bleasdell, Gwenyth,Lipay, Josh,Ferandin, Yoan,Meijer, Laurent,Madura, Jeffry D.
experimental part, p. 359 - 373 (2011/02/27)
Alzheimer's disease (AD) is a progressive neurodegenerative disease resulting in cognitive and behavioral impairment. The two classic pathological hallmarks of AD include extraneuronal deposition of amyloid β (Aβ) and intraneuronal formation of neurofibri
A NOVEL ROUTE TO 1-(N,N-DIMETHYLAMINO)-2-BUTANOL
Sard, Howard,Duffley, Richard P.,Razdan, Raj K.
, p. 813 - 816 (2007/10/02)
The title compound can be readily synthesized under mild conditions via addition of lithium dimethylamide to 1,2-epoxybutane.
Stereospecific Palladium-Promoted Oxyamination of Alkenes
Baeckvall, Jan E.,Bjoerkman, Eva E.
, p. 2893 - 2898 (2007/10/02)
A method for direct oxyamination of olefins to vicinal amino alcohol derivatives is described. The reaction proceeds via an aminopalladation-oxidation sequence.Terminal olefins give good yields (60-80percent) whereas internal olefins give lower yields (20-60percent).The oxyamination reaction is stereospecific as shown by reaction of (Z)- and (E)-2-butene and (E)-1-deuterio-1-decene and proceeds by overall cis stereochemistry.The stereochemical outcome is a result of a trans aminopalladation followed by an oxidative cleavage of the palladium carbon bond with inversion of configuration at carbon.Oxidation of the organopalladium ? complex to give an oxidized palladium intermediate, which could be a Pd(IV) intermediate, followed by SN2-type nucleophilic displacement of palladium is the most likely mechanism for the oxidative cleavage reaction.
