34489-36-6Relevant academic research and scientific papers
Pd(II)-catalyzed hydroxyl-directed C-H olefination enabled by monoprotected amino acid ligands
Lu, Yi,Wang, Dong-Hui,Engle, Keary M.,Yu, Jin-Quan
supporting information; experimental part, p. 5916 - 5921 (2010/07/05)
A novel Pd(II)-catalyzed ortho-C-H olefination protocol has been developed using spatially remote, unprotected tertiary, secondary, and primary alcohols as the directing groups. Mono-N-protected amino acid ligands were found to promote the reaction, and an array of olefin coupling partners could be used. When electron-deficient alkenes were used, the resulting olefinated intermediates underwent subsequent Pd(II)-catalyzed oxidative intramolecular cyclization to give the corresponding pyran products, which could be converted into ortho-alkylated alcohols under hydrogenolysis conditions. The mechanistic details of the oxidative cyclization step are discussed and situated in the context of the overall catalytic cycle.
Synthesis and antiprotozoal activities of simplified analogs of naphthylisoquinoline alkaloids
Bringmann, Gerhard,Brun, Reto,Kaiser, Marcel,Neumann, Stefan
, p. 32 - 42 (2008/09/16)
The naphthylisoquinoline alkaloids (NIQs) represent a class of natural products with manifold activities against various tropical diseases. They are isolated from rare and difficult-to-cultivate tropical plants. In order to find novel, more easily accessi
3,3-DIMETHYL-8-OXOISOQUINOLINES FOR MEDICAL PURPOSES, METHODS FOR THE PRODUCTION THEREOF, MEDICAMENTS CONTAINING SAID COMPOUNDS AND THE USE OF THE SAME
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Page 13; 14, (2010/02/07)
The invention relates to compounds (3,3-dimethyl-8-oxoisoquinoline derivatives) of general formulae (I) and (II), and to methods for the production thereof. Said 3,3-dimethyl-8-oxoisoquinolines have antiviral and antitumour characteristics in cell culture
