345-06-2

Basic information

• Product Name: 2-(4-fluorophenyl)-3-methyl-1H-indole
• Synonyms: 2-(4-fluorophenyl)-3-methyl-1H-indole
• CAS NO: 345-06-2
• Molecular Weight: 225.265
• Mol File: 345-06-2.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: 2-(4-fluorophenyl)-3-methyl-1H-indole(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-fluorophenyl)-3-methyl-1H-indole(345-06-2)
• EPA Substance Registry System: 2-(4-fluorophenyl)-3-methyl-1H-indole(345-06-2)

Safety Data

• Hazardous Substances Data: 345-06-2(Hazardous Substances Data)

Upstream product

• 1433772-22-5 N'-(1-(2-aminophenyl)ethylidene)-4-methylbenzenesulfonohydrazide 
• 459-57-4 4-fluorobenzaldehyde 
• 551-93-9 2-aminoacetophenone 
• 456-03-1 1-(4-fluorophenyl)propan-1-one 
• 59-88-1 phenylhydrazine hydrochloride 
• 100-63-0 phenylhydrazine 
• 462-06-6 fluorobenzene 

Relevant articles and documents

Synthesis of Ester-Substituted Indolo[2,1-a]isoquinolines via Photocatalyzed Alkoxycarbonylation/Cyclization Reactions

A direct alkoxycarbonylation/cyclization reaction is accomplished under visible light-induced photoredox catalysis. With this approach, a variety of ester-substituted indolo[2,1-a]isoquinolines are prepared in good to excellent yields. It is worth noting that this method not only can afford the synthesis of indolo[2,1-a]isoquinolines but also can provide an alternative route for generating complex target structures bearing carboxylic esters.

Visible-Light Photocatalytic Tri- A nd Difluoroalkylation Cyclizations: Access to a Series of Indole[2,1- A[isoquinoline Derivatives in Continuous Flow

A process for achieving photocatalyzed tri- A nd difluoromethylation/cyclizations for constructing a series of tri-or difluoromethylated indole[2,1-a]isoquinoline derivatives is described. This protocol utilized an inexpensive organic photoredox catalyst and provided good yields. Moreover, the combination of continuous flow and photochemistry, designed to provide researchers with a unique green process, was also shown to be key to allowing the reaction to proceed (product yield of 83% in flow vs 0% in batch).

Base-promoted domino reaction for the synthesis of 2,3-disubstituted indoles from 2-aminobenzaldehyde/2-amino aryl ketones, tosylhydrazine, and aromatic aldehydes

A base-promoted domino reaction to synthesize the 2,3-disubstituted indoles from 2-aminobenzaldehyde/2-amino aryl ketones, tosylhydrazine, and aromatic aldehydes has been developed. This strategy provides a simple and beneficial way for the construction of 2,3-disubstituted indole compounds from readily available starting materials under mild conditions.