345216-96-8

Basic information

• Product Name: Ethyl 4-acetyl tetrahydro-2H-pyran-4-carboxylate
• Synonyms: methyl 4-acetyl-tetrahydro-2H-pyran-4-carboxylate
• CAS NO: 345216-96-8
• Molecular Formula: C10H16O4
• Molecular Weight: 200.23164
• Mol File: 345216-96-8.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 279.864°C at 760 mmHg
• Flash Point: 119.108°C
• Appearance: /
• Density: 1.104g/cm³
• Vapor Pressure: 0.004mmHg at 25°C
• Refractive Index: 1.457
• CAS DataBase Reference: Ethyl 4-acetyl tetrahydro-2H-pyran-4-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: Ethyl 4-acetyl tetrahydro-2H-pyran-4-carboxylate(345216-96-8)
• EPA Substance Registry System: Ethyl 4-acetyl tetrahydro-2H-pyran-4-carboxylate(345216-96-8)

Safety Data

• Hazardous Substances Data: 345216-96-8(Hazardous Substances Data)

Usage

InChI:InChI=1/C10H16O4/c1-3-14-9(12)10(8(2)11)4-6-13-7-5-10/h3-7H2,1-2H3

Upstream product

• 105-45-3 acetoacetic acid methyl ester 
• 111-44-4 3-oxa-1,5-dichloropentane 

Downstream Products

• 1560898-08-9 ethyl 4-((E)-phenyldiazenyl)-3-(tetrahydro-2H-pyran-4-yl)-1H-pyrazole-5-carboxylate 
• 1560898-04-5 ethyl (E)-2,4-dioxo-3-(phenyldiazenyl)-4-(tetrahydro-2H-pyran-4-yl)butanoate 
• 1295521-50-4 4-(1-(2-pyrrolidin-1-yl-ethyl)-4-(tetrahydro-pyran-4-yl)-1H-imidazol-2-yl)-piperidine 
• 137052-08-5 1-(tetrahydro-2H-pyran-4-yl)ethan-1-one 

Relevant articles and documents

PYRAZOLO[4,3-D]PYRIMIDIN-7(6H)-ONE DERIVATIVES AS PDE9 INHIBITORS

Pyrazolo[4,3-d]pyrimidin-7(6H)-one derivatives represented by the general formula (I), wherein R1 represents hydrogen atom or methyl; when R1 represents hydrogen atom, then R2 represents cyclopentyl, tetrahydropyranyl, cyclohexyl, or cyclohexyl substituted with 1 or 2 halogen atoms; when R1 represents methyl, then R2 represents cyclopentyl; R3 is selected from the group consisting of phenyl unsubstituted or substituted with 1 to 3 substituents selected from F, Cl, Br, I, and OCH3; and 6- to 10-membered heteroaryl with 1 to 3 heteroatoms selected independently form O, N and S; and Q represents C1-C3-alkylene group, which is unsubstituted or substituted with 1 to 3 C1-C3-alkyl groups; and their salts. The compounds are PDE9A inhibitors useful as m edicaments, in particular for treatment of cognitive function disorders and neurodegenerative diseases

PROCESSES FOR PRODUCING ALKYL 3-(4-TETRAHYDROPYRANYL)-3-OXOPROPIONATE COMPOUND AND 4-ACYLTETRAHYDROPYRAN

The present invention is to provide a process for preparing an alkyl 3-(4-tetrahydropyranyl)-3-oxopropanoate compound represented by the formula (1): wherein R1 and R2 may be the same or different from each other, and represent a group which does not participate in the reaction, and R1 and R2 may be bonded to form a ring, and the ring may contain a hetero atom(s), and R3 represents a hydrocarbon group, which comprises reacting 4-acyltetrahydropyran represented by the formula (2): wherein R1 and R2 have the same meanings as defined above, and a carbonic acid diester represented by the formula (3): wherein R3 has the same meanings as defined above, and two R3s may be bonded to each other to form a ring, in the presence of a base, and a process for preparing 4-acyltetrahydropyran.