Ethyl 4-acetyl tetrahydro-2H-pyran-4-carboxylate

Base Information

• Chemical Name: Ethyl 4-acetyl tetrahydro-2H-pyran-4-carboxylate
• CAS No.: 345216-96-8
• Molecular Formula: C10H16O4
• Molecular Weight: 200.23164
• Mol file: 345216-96-8.mol

Synonyms:2H-pyran-4-carboxylic acid, 4-acetyltetrahydro-, ethyl ester

Chemical Property of Ethyl 4-acetyl tetrahydro-2H-pyran-4-carboxylate

Chemical Property:

• Vapor Pressure: 0.004mmHg at 25°C
• Boiling Point: 279.864°C at 760 mmHg
• Flash Point: 119.108°C
• PSA: 52.60000
• Density: 1.104g/cm³
• LogP: 0.54520

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Ethyl 4-acetyl tetrahydro-2H-pyran-4-carboxylate

There total 1 articles about Ethyl 4-acetyl tetrahydro-2H-pyran-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

acetoacetic acid methyl ester (105-45-3) + 3-oxa-1,5-dichloropentane (111-44-4) → methyl 4-acetyl-tetrahydro-2H-pyran-4-carboxylate (345216-96-8)

Guidance literature:

With potassium carbonate; potassium iodide; In N,N-dimethyl-formamide; at 80 ℃; for 8h;

Reference yield: 96.0%

methyl 4-acetyl-tetrahydro-2H-pyran-4-carboxylate (345216-96-8) → 1-(tetrahydro-2H-pyran-4-yl)ethan-1-one (137052-08-5)

Guidance literature:

With sulfuric acid; water; at 120 ℃; for 1.5h; Product distribution / selectivity;

Reference yield:

methyl 4-acetyl-tetrahydro-2H-pyran-4-carboxylate (345216-96-8) → ethyl 4-((E)-phenyldiazenyl)-3-(tetrahydro-2H-pyran-4-yl)-1H-pyrazole-5-carboxylate (1560898-08-9)

Guidance literature:

Multi-step reaction with 4 steps

1: sulfuric acid / water; isopropyl alcohol / 48 h / Reflux

2: sodium ethanolate / ethanol / 3 h / 0 - 20 °C

3: sodium acetate / ethanol; water / 18 h / 0 °C

4: acetic acid; hydrazine hydrate / 18 h / 20 °C

With sulfuric acid; sodium ethanolate; sodium acetate; hydrazine hydrate; acetic acid; In ethanol; water; isopropyl alcohol;

upstream raw materials:

acetoacetic acid methyl ester

3-oxa-1,5-dichloropentane

Downstream raw materials:

1-(tetrahydro-2H-pyran-4-yl)ethan-1-one

4-(1-(2-pyrrolidin-1-yl-ethyl)-4-(tetrahydro-pyran-4-yl)-1H-imidazol-2-yl)-piperidine

ethyl (E)-2,4-dioxo-3-(phenyldiazenyl)-4-(tetrahydro-2H-pyran-4-yl)butanoate

ethyl 4-((E)-phenyldiazenyl)-3-(tetrahydro-2H-pyran-4-yl)-1H-pyrazole-5-carboxylate