34552-14-2

Basic information

• Product Name: 3-AMINO-2-BROMO-5-PICOLINE
• Synonyms: 3-AMINO-2-BROMO-5-PICOLINE;2-BROMO-3-AMINO-5-PICOLINE;2-Bromo-3-amino-5-bromopyridine;2-Bromo-5-methyl-3-pyridinamine;5-Amino-6-bromo-3-picoline;2-Bromo-5-methylpyridin-3-amine, 5-Amino-6-bromo-3-picoline;2-broMo-5-Methylpyridin-3-aMine;2-BroMo-3-AMino-5-Methyl Pyridine
• CAS NO: 34552-14-2
• Molecular Formula: C6H7BrN2
• Molecular Weight: 187.04
• Product Categories: Pyridine;Heterocycle-Pyridine series
• Mol File: 34552-14-2.mol
• Article Data: 3

Chemical Properties

• Melting Point: 103-106℃
• Boiling Point: 310 °C at 760 mmHg
• Flash Point: 141.3 °C
• Appearance: /
• Density: 1.593 g/cm³
• Vapor Pressure: 0.000617mmHg at 25°C
• Refractive Index: 1.617
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 2.02±0.20(Predicted)
• CAS DataBase Reference: 3-AMINO-2-BROMO-5-PICOLINE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-AMINO-2-BROMO-5-PICOLINE(34552-14-2)
• EPA Substance Registry System: 3-AMINO-2-BROMO-5-PICOLINE(34552-14-2)

Safety Data

• TSCA: N
• Hazardous Substances Data: 34552-14-2(Hazardous Substances Data)

Usage

General Description

3-AMINO-2-BROMO-5-PICOLINE is a chemical compound with the formula C6H6BrN2. It is a derivative of pyridine and contains a bromine atom and an amino group attached to the pyridine ring. It is commonly used as an intermediate in the synthesis of various pharmaceuticals and agrochemicals. 3-AMINO-2-BROMO-5-PICOLINE is also used as a building block in the production of organic compounds and can be found in research laboratories as a reagent for chemical reactions. It is important to handle this chemical with care as it can be harmful if it comes into contact with the skin, eyes, or is ingested.

InChI:InChI=1/C6H7BrN2/c1-4-2-5(8)6(7)9-3-4/h2-3H,8H2,1H3

Upstream product

• 23056-46-4 2-bromo-5-methyl-3-nitropyridine 
• 3430-19-1 5-methylpyridin-3-amine 

Relevant articles and documents

PYRROLIDINYL UREA, THIOUREA, GUANIDINE AND CYANOGUANIDINE COMPOUNDS AS TRKA KINASE INHIBITORS

Compounds of Formula (I): or stereoisomers, tautomers, or pharmaceutically acceptable salts, or solvates or prodrugs thereof, where R1, R2, Ra, Rb, Rc, Rd, X, Ring B, and Ring C are as defined herein, and wherein Ring B moiety and the NH-C(=X)-NH moiety are in the trans configuration, are inhibitors of TrkA kinase and are useful in the treatment of diseases which can be treated with a TrkA kinase inhibitor such as pain, cancer, inflammation/inflammatory diseases, neurodegenerative diseases, certain infectious diseases, Sjogren's syndrome, endometriosis, diabetic peripheral neuropathy, prostatitis and pelvic pain syndrome.

Bromination of Pyridines. II. Bromination of Aminopicolines

The bromination of all ten possible aminopicolines 1-10 was investigated.In general, the major brominated product was that corresponding to electrophilic attack at the sites para or ortho to the amino group.