3457-91-8

Usage

InChI:InChI=1/C4H8N2O6/c7-5(8)11-3-1-2-4-12-6(9)10/h1-4H2

Upstream product

• 137-40-6 sodium proprionate 
• 110-63-4 Butane-1,4-diol 

Downstream Products

• 109-99-9 tetrahydrofuran 
• 50-00-0 formaldehyd 
• 74-85-1 ethene 
• 860005-21-6 4-(nitrooxy)butyl [1α(Z),2β(R),3α,5α]-7-[3,5-dihydroxy-2-((3R)-3-hydroxy-5-phenylpentyl)cyclopentyl]-5-heptenoate 
• 110-63-4 Butane-1,4-diol 
• 163133-43-5 naproxcinod 

Relevant academic research and scientific papers

PROCESS FOR THE PRODUCTION OF ESTERS OF NITRIC ACID

Organic nitrates are prepared from mono-, di- or polyhydric alcohols by (i) simultaneously feeding a first continuous-flow microreactor unit with (a) concentrated nitric acid, (b) acetic anhydride, (c) optionally, a catalytic amount of a strong inorganic acid other than nitric acid, and (d) optionally, a solvent, to obtain a solution of acetyl nitrate, and (ii) simultaneously feeding a second continuous-flow microreactor with the solution of acetyl nitrate obtained in step (i) and said mono-, di- or polyhydric alcohol in liquid form or dissolved in a solvent to obtain a solution of said organic nitrate, and (iii) optionally, isolating said organic nitrate from the solution obtained in step (ii). The process of the invention is particularly suited for mono-nitration of dihydric alcohols such as 1,4-butanediol.

FORMATION OF NITRATE ESTERS IN MICROREACTORS AND MILLIREACTORS USING A CONTINUOUS PRODUCT EXTRACTION IN A TURBULENT FLOW REGIME

A process for the continuous production of a compound of Formula (II), HO-R1-ONO2 (II) wherein R1 is a straight chain alkyl radical having from 3 to 6 carbon atoms, in a two-phase solvent system, comprising contacting a compound of Formula (I), HO-R1-OH (I) wherein R1 is as defined above, with nitric acid in the presence of a first solvent, wherein the compound of Formula (II) is continuously extracted into a second solvent, and the reaction is carried out in a mixing microreactor which provides a power loss of at least 1.3 times the power loss provided under identical conditions by a circular cross-section straight-channel microreactor having an internal diameter equal to the average hydraulic diameter of the mixing microreactor and a length equal to the length of the mixing microreactor.

Method for the preparation of organic nitrates

The present invention relates to a process for the preparation of organic nitrates having at least one nitryloxy and at least one hydroxy group, wherein the at least one hydroxy group may be present in form of an esterified hydroxy residue, the latter bei

A PROCESS FOR THE MONONITRATION OF ALKANEDIOLS

A process for the preparation of compounds of formula: HO-A-ONO2 (I) wherein A is a C2-C6 alkylene chain by nitration of the corresponding alkanediols with "stabilised" nitric acid is herein disclosed. The process is safer to operators and allows to obtain advantageous yields on an industrial scale.

A PROCESS FOR THE PURIFICATION OF 1,4-BUTANEDIOL MONONITRATE

A process for the purification of 1,4-butanediol mononitrate from 1,4-butanediol dinitrate and 1,4-butanediol, by selective extraction with solvents is herein disclosed.