38239-55-3

Usage

Uses

Used in Traditional Medicine:
Curcumin is used as a traditional medicine for treating digestive issues, skin diseases, and wounds due to its anti-inflammatory and antioxidant properties.
Used in Pharmaceutical Applications:
In the pharmaceutical industry, curcumin is being researched for its potential as a treatment for various diseases, including cancer, arthritis, and Alzheimer's disease, owing to its demonstrated therapeutic effects.
Used in Food Industry:
Curcumin is commonly used as a food additive and coloring agent, providing a vibrant yellow hue to various dishes and products.
Used as a Dietary Supplement:
Curcumin is also available as a dietary supplement, considered safe for consumption in moderate amounts. However, high doses may lead to gastrointestinal discomfort.

Upstream product

• 123-08-0 4-hydroxy-benzaldehyde 
• 98-86-2 acetophenone 
• 6515-21-5 4-methoxymethoxy-benzaldehyde 
• 100-52-7 benzaldehyde 
• 99-93-4 4-Hydroxyacetophenone 
• 70-11-1 α-bromoacetophenone 
• 22252-15-9 trans-4-methoxychalcone 
• 13735-81-4 1-styrenyloxytrimethylsilane 
• 7400-08-0 p-Coumaric Acid 
• 611-73-4 Benzoylformic acid 
• 123-11-5 4-methoxy-benzaldehyde 
• 108-46-3 recorcinol 
• 89-84-9 2',4'-dihydroxy-4-acetophenone 
• 22966-09-2 (2E)-3-(4-bromophenyl)-1-phenylprop-2-en-1-one 

Downstream Products

• 74642-73-2 Acetic acid (2S,3R,4S,5R,6R)-3-acetoxy-6-acetoxymethyl-2-[4-((E)-3-oxo-3-phenyl-propenyl)-phenoxy]-5-((2S,3R,4S,5R,6R)-3,4,5-triacetoxy-6-acetoxymethyl-tetrahydro-pyran-2-yloxy)-tetrahydro-pyran-4-yl ester 
• 74629-62-2 Acetic acid (2S,3R,4S,5R,6R)-4,5-diacetoxy-6-acetoxymethyl-2-[4-((E)-3-oxo-3-phenyl-propenyl)-phenoxy]-tetrahydro-pyran-3-yl ester 
• 17791-25-2 3-(4-hydroxyphenyl)-1-phenylpropan-1-one 
• 312700-16-6 4-(3-chloropropoxy)chalcone 
• 123-08-0 4-hydroxy-benzaldehyde 
• 98-86-2 acetophenone 
• 74629-69-9 2-(4-hydroxyphenyl)-4-phenyl-2,3-dihydro-1,5-benzothiazepine 
• 959863-11-7 C₂₈H₂₈O₄ 
• 959863-12-8 C₃₀H₃₂O₄ 
• 959863-07-1 C₂₄H₂₀O₄ 
• 959863-13-9 C₃₂H₃₆O₄ 
• 959863-08-2 C₂₅H₂₂O₄ 
• 959863-10-6 C₂₇H₂₆O₄ 
• 959863-14-0 C₃₄H₄₀O₄ 

Relevant academic research and scientific papers

The metal sensing applications of chalcones: The synthesis, characterization and theoretical calculations

In this study, three different chalcone compounds were synthesized by Aldol condensation reaction. 4-hydroxybenzaldehyde and ketone compounds (acetophenone, acetofuran and thio acetofuran) were reacted in ethanol in harsh alkaline media provided by potass

Aldoxime- and hydroxy-functionalized chalcones as highly potent and selective monoamine oxidase-B inhibitors

A panel of 30 chalcone derivatives, including 19 aldoxime-chalcone ethers (ACE), and 11 hydroxyl?chalcones (HC), previously synthesized using a Pd-catalyzed C–O cross-coupling method were evaluated for their inhibitory activities against monoamine oxidases (MAOs), cholinesterases (ChEs), and β-secretase (BACE-1). HC6 was the most potent inhibitor of MAO-B with an IC50 value of 0.0046 μM and a selectivity index (SI) of 1,113. HC3 also potently inhibited MAO-B (IC50 = 0.0067 μM) and had the highest SI (1,455). ACE7 and ACE15 were also potent MAO-B inhibitors (IC50 = 0.012 and 0.018 μM, respectively), with SIs of 260 and 1,161, respectively. HC3 and HC6 were reversible competitive inhibitors of MAO-B, with Ki values of 0.0036 and 0.0013 μM, respectively. A structure–activity relationship revealed that methyl and fluorine substituents contributed to increasing both inhibition and selectivity. ACE7 was the most effective inhibitor of MAO-A (IC50 = 1.49 μM), followed by ACE3 (IC50 = 3.75 μM). No compounds effectively inhibited AChE, BChE, or BACE-1. A docking simulation showed that the ligand efficiency and docking scores of HC3 and HC6 toward MAO-B were consistent with the experimental IC50 values. These results suggest that HC3 and HC6 can be considered promising candidates for the treatment of neurological disorders.

A new method for the synthesis of chalcone derivatives promoted by PPh3/I2under non-alkaline conditions

A straightforward and general method has been developed for the synthesis of chalcone derivatives by a Claisen-Schmidt reaction in the presence of PPh3/I2 in 1,4-dioxane under reflux temperatures. With the condensation of the aromatic ketone and aldehyde occurring at non-strongly alkaline conditions, our proposed method significantly expands the range of applicable substrates, especially for groups that are unstable under alkaline conditions.

Combined 3D-QSAR and docking analysis for the design and synthesis of chalcones as potent and selective monoamine oxidase B inhibitors

Monoamine oxidases (MAOs) are important targets in medicinal chemistry, as their inhibition may change the levels of different neurotransmitters in the brain, and also the production of oxidative stress species. New chemical entities able to interact selectively with one of the MAO isoforms are being extensively studied, and chalcones proved to be promising molecules. In the current work, we focused our attention on the understanding of theoretical models that may predict the MAO-B activity and selectivity of new chalcones. 3D-QSAR models, in particular CoMFA and CoMSIA, and docking simulations analysis have been carried out, and their successful implementation was corroborated by studying twenty-three synthetized chalcones (151–173) based on the generated information. All the synthetized molecules proved to inhibit MAO-B, being ten out of them MAO-B potent and selective inhibitors, with IC50 against this isoform in the nanomolar range, being (E)-3-(4-hydroxyphenyl)-1-(2,2-dimethylchroman-6-yl)prop-2-en-1-one (152) the best MAO-B inhibitor (IC50 of 170 nM). Docking simulations on both MAO-A and MAO-B binding pockets, using compound 152, were carried out. Calculated affinity energy for the MAO-A was +2.3 Kcal/mol, and for the MAO-B was ?10.3 Kcal/mol, justifying the MAO-B high selectivity of these compounds. Both theoretical and experimental structure–activity relationship studies were performed, and substitution patterns were established to increase MAO-B selectivity and inhibitory efficacy. Therefore, we proved that both 3D-QSAR models and molecular docking approaches enhance the probability of finding new potent and selective MAO-B inhibitors, avoiding time-consuming and costly synthesis and biological evaluations.

Inhibition of Caco-2 and MCF-7 cancer cells using chalcones: synthesis, biological evaluation and computational study

Cancer is the second death cause worldwide, with breast and colon cancer among the most prevalent types. Traditional treatment strategies have several side effects that inspire the development of novel anticancer agents derived from natural sources, like chalcone derivatives. For this investigation, twenty-three chalcones (4a-w) were synthesized and evaluated as antiproliferative agents against MCF-7 and Caco-2 cells, finding three and two compounds with similar or higher antiproliferative activity than daunorubicin, while only two chalcones showed better selectivity indexes than daunorubicin on MCF-7. From these results, we developed good-performance QSAR models (r > 0.850, q2>0.650), finding several structural features that could modify chalcone activity and selectivity. According to these models, chalcones 4w and 4t have high potency and selectivity against Caco-2 and MCF-7, respectively, which make them attractive candidates for hit-to-lead development of ROS-independent pro apoptotic agents.

Acrylate-substituted pyrazoline derivative, photocurable composition and preparation method

The present application relates to an acrylate-substituted pyrazoline derivative represented by formula (I), a photocurable composition, and a preparation method and application of the acrylate-substituted pyrazoline derivative represented by formula (I).

Antibacterial and anti-inflammatory activity of valproic acid-pyrazole conjugates as a potential agent against periodontitis

Periodontitis is a serious global concern. Therefore, in the present study, we intend to synthesize novel valproic-acid pyrazole conjugates as a novel agent against periodontitis. The molecules were developed in a facile synthetic route and obtained in ex

Phenazine-chalcone hybrid compound as well as preparation method and application thereof

The invention discloses a phenazine-chalcone hybrid compound, a preparation method thereof and application thereof in preparation of anti-brain glioma drugs. The structure of the phenazine-chalcone hybrid compound is shown as a formula (I). Compared with

Antimicrobial, structure-activity relationship and computational studies of some synthesized chalcone derivatives

Several chalcones viz. 1,3-diaryl-2-propane-1-one (1a), 3-(4-hydroxy phenyl)-1-phenyl-2-propane-1-one (1b), 3-(4-amino-phenyl)-1-phenyl-2-propane-1-one (1c) and their derivatives 2-ethoxy-4,6-diphenyl-4H-pyran-3-carboxylic acid ethyl ester (2a), 4-(4-hydr

Efficient solvent- And temperature-tuned access to aldoxime ethers and phenolic functions by Pd-catalyzed C-O cross-coupling of aldoximes with aryl bromides and bromo-chalcones

A single method with a functionality switching option was developed for the first time for the Pd-catalyzed C-O cross-coupling of aryl bromides and bromo-chalcones with aldoximes. The ligand tBuXPhos (L2) was found to be an effective supporting ligand for the Pd-catalyzed coupling of aldoximes with bromo coupling partners. The functionality switching from oxime ethers to a phenolic or hydroxy group was driven by solvent or temperature. This method offers the products in good to excellent yields in short reaction times.