34597-04-1

Upstream product

• 23138-72-9 N-trimethylsilyle du N-ethylacetamide 
• 100-39-0 benzyl bromide 
• 772-54-3 N,N-diethylbenzylamine 
• 74-96-4 ethyl bromide 
• 64-19-7 acetic acid 
• 100-46-9 benzylamine 
• 62673-31-8 benzyl(bromo)zinc 
• 14321-27-8 N-ethylbenzylamine 
• 75-36-5 acetyl chloride 
• 108-24-7 acetic anhydride 
• 40596-41-6 Benzyl-ethyl-((Z)-3-phenyl-allyl)-amine 
• 40596-39-2 Ethyl-benzyl-methallylamin 

Downstream Products

• 17847-35-7 ethyl[(4-nitrophenyl)methyl]amine 
• 14321-27-8 N-ethylbenzylamine 
• 772-54-3 N,N-diethylbenzylamine 

Relevant academic research and scientific papers

Direct Reductive N-Functionalization of Aliphatic Nitro Compounds

The first general protocol for the direct reductive N-functionalization of aliphatic nitro compounds is presented. The nitro group is partially reduced to a nitrenoid, with a mild and readily available combination of B2pin2 and zinc organyls. Thereby, the formation of an unstable nitroso intermediate is avoided, which has so far severely limited reductive transformations of aliphatic nitro compounds. The reaction is concluded by an electrophilic amination of zinc organyls.

A process for preparing 4 - amino - N - alkyl benzyl amine method

The present invention belongs to an organic intermediate preparation, and particularly relates to a 4-amino-N-alkyl benzylamine preparation method. According to the present invention, N-alkyl benzylamine is adopted as a raw material, acetylation, positioning nitrification and deprotection are performed, and hydrogenation reducing is performed in the presence of a multi-component skeleton Ni-Fe-Cu catalyst, wherein the total yield is more than or equal to 90%; and the method has characteristics of simple process, mild operating conditions and low pollution, the catalyst used in the reaction has high activity and high selectivity, the catalytic hydrogenation selectivity is more than or equal to 99.9%, the yield is more than or equal to 99.9%, the catalyst can be repeatedly applied, and the production cost can be effectively reduced compared with the traditional process.

Catalytic N-Alkylation of Amines Using Carboxylic Acids and Molecular Hydrogen

A convenient, practical and green N-alkylation of amines has been accomplished by applying readily available carboxylic acids in the presence of molecular hydrogen. Applying an in situ formed ruthenium/triphos complex and an organic acid as cocatalyst, a broad range of alkylated secondary and tertiary amines are obtained in good to excellent yields. This novel method is also successfully applied for the synthesis of unsymmetrically substituted N-methyl/alkyl anilines through a direct three-component coupling reaction of the corresponding amines, carboxylic acids, and CO2 as a C1 source.

Oxidation of benzylamines to amides

A convenient method for the conversion of tertiary benzylamines to benzamides by phase transfer oxidation is described. Yields are good. Regioselectivities are reported.