3461-34-5Relevant articles and documents
Reactions of vinyl type carbocations generated in fluorosulfonic acid with benzene derivatives. New synthesis of alkyl 3,3-diarylpropenoates
Savechenkov,Rudenko,Vasil'ev,Fukin
, p. 1316 - 1328 (2005)
Vinyl type carbocations ArC+=CHX [X = CO2H, CO 2Alk, C≡N, P(O)(OAlk)2] generated from alkyl 3-arylpropynoates and related compounds in fluorosulfonic acid at -75 to -20°C react with various benzene derivatives,
MALIC ENZYME INHIBITORS
-
Page/Page column 97-98, (2021/04/23)
The present invention relates to novel compounds useful as malic enzyme (ME) inhibitors, processes for their preparation and use of these compounds for the therapeutic treatment of disorders mediated by ME such as cancers (e.g. pancreatic ductal adenocarcinoma (PDAC)) in humans.
Rh-Catalyzed Direct Carboxylation of Alkenyl C?H Bonds of Alkenylpyrazoles
Saitou, Takanobu,Jin, Yushu,Isobe, Kotaro,Suga, Takuya,Takaya, Jun,Iwasawa, Nobuharu
, p. 1941 - 1944 (2020/06/10)
The Rh-catalyzed direct carboxylation of alkenyl C?H bonds was achieved by using pyrazole as a removable directing group. In the presence of 5 mol% RhCl3 ? 3H2O, 6 mol% P(Mes)3, and 2 equiv. of AlMe2(OMe), the alkenyl C?H bond of various alkenylpyrazoles was directly carboxylated in good yields under CO2 atmosphere. Furthermore, several useful transformations of the pyrazole moiety of the product were achieved to afford synthetically useful carboxylic acid derivatives in good yields.