3461-34-5

Usage

Uses

Used in Cosmetic and Personal Care Industry:
Methyl 3,3-diphenyl-2-propenoate is used as a flavor and fragrance ingredient for its fruity odor, enhancing the sensory experience of cosmetic and personal care products.
Used in Pharmaceutical Industry:
Methyl 3,3-diphenyl-2-propenoate is used in the production of pharmaceuticals, contributing to the development of new medications and therapies.
Used in Organic Synthesis:
Methyl 3,3-diphenyl-2-propenoate serves as an intermediate in organic synthesis, facilitating the creation of various chemical compounds and products.
Used in Chemical Industry:
Methyl 3,3-diphenyl-2-propenoate is used as a building block in the chemical industry, playing a crucial role in the synthesis of a wide range of chemical products.

Upstream product

• 186581-53-3 diazomethane 
• 13249-58-6 1-bromo-2,2-diphenylethylene 
• 124-38-9 carbon dioxide 
• 67-56-1 methanol 
• 13311-00-7 2,2-Dimethyl-5-(diphenylmethylene)-1,3-dioxane-4,6-dione 
• 201230-82-2 carbon monoxide 
• 51664-93-8 β-phenylstyrylmercury acetate 
• 57090-79-6 1,1,4,4-tetraphenyl-3-buten-2-one 
• 103-26-4 Methyl cinnamate 
• 4528-64-7 4,4-diphenyl-2-cyclohexen-1-one 
• 74-88-4 methyl iodide 
• 119-61-9 benzophenone 
• 116-54-1 dichloroacetic acid methyl ester 
• 591-50-4 iodobenzene 

Downstream Products

• 4541-91-7 2-bromo-3,3-diphenyl-acrylic acid 
• 20797-50-6 3,3-bis-(4-nitro-phenyl)-acrylic acid 
• 10338-20-2 2-(3,3-Diphenyl-propen-2-yl)-3-phytyl-naphthochinon-1,4 
• 10338-00-8 2-(3,3-Diphenyl-propen-2-yl)-1,4-diacetoxynaphthalin 
• 10338-19-9 2-(3,3-Diphenyl-propen-2-yl)-3-(3-methyl-buten-2-yl)-naphthochinon-1,4 
• 10337-99-2 2-(3,3-Diphenyl-propen-2-yl)-naphthochinon-1,4 
• 252770-39-1 1-(3,3-dimethyl-2-oxo-pentanoyl)-piperidine-2-carbothioic acid S-(3,3-diphenyl-propyl) ester 

Relevant academic research and scientific papers

Reactions of vinyl type carbocations generated in fluorosulfonic acid with benzene derivatives. New synthesis of alkyl 3,3-diarylpropenoates

Vinyl type carbocations ArC+=CHX [X = CO2H, CO 2Alk, C≡N, P(O)(OAlk)2] generated from alkyl 3-arylpropynoates and related compounds in fluorosulfonic acid at -75 to -20°C react with various benzene derivatives,

A Solid-Phase Assisted Flow Approach to In Situ Wittig-Type Olefination Coupling

Described herein is the development of a continuous flow, solid-phase triphenylphosphine (PS-PPh3) assisted protocol to facilitate the in situ coupling of reciprocal pairs of halogen and carbonyl functionalised molecular pairs by a Wittig olefination within 15 mins. The protocol entails injecting a single solution (1 : 1 CHCl3 : EtOH) containing the halogenated and carbonyl-based substrates into a continuously flowing stream of CHCl3 : EtOH (1 : 1), passed through a fixed bed of K2CO3 and PS-PPh3. With advancement to the previous PS-PPh3 coupling procedures, the method employs a traditional polystyrene-based immobilisation matrix, the substrate scope of the protocol extended to substituted ketones, secondary alkyl chlorides, and an unprotected maleimide scaffold.

MALIC ENZYME INHIBITORS

The present invention relates to novel compounds useful as malic enzyme (ME) inhibitors, processes for their preparation and use of these compounds for the therapeutic treatment of disorders mediated by ME such as cancers (e.g. pancreatic ductal adenocarcinoma (PDAC)) in humans.

Remote and Selective C(sp2)-H Olefination for Sequential Regioselective Linkage of Phenanthrenes

Biphenylcarboxylic acid with two competing C(sp2)-H sites was designed for site selective C(sp2)-H functionalization by developing carboxylic acids assisted remote and selective olefination via 7-membered palladacycle. Mechanism investigation and DFT calculations reveal a kinetics-determined process, which could be utilized to explore a variety of remote site selectivity. The practicability of this method was highlighted by the precise construction of phenathrene under sequential site selectivity.

Rh-Catalyzed Direct Carboxylation of Alkenyl C?H Bonds of Alkenylpyrazoles

The Rh-catalyzed direct carboxylation of alkenyl C?H bonds was achieved by using pyrazole as a removable directing group. In the presence of 5 mol% RhCl3 ? 3H2O, 6 mol% P(Mes)3, and 2 equiv. of AlMe2(OMe), the alkenyl C?H bond of various alkenylpyrazoles was directly carboxylated in good yields under CO2 atmosphere. Furthermore, several useful transformations of the pyrazole moiety of the product were achieved to afford synthetically useful carboxylic acid derivatives in good yields.

Copper-Catalyzed 1,2-Methoxy Methoxycarbonylation of Alkenes with Methyl Formate

Reported here is a copper-catalyzed 1,2-methoxy methoxycarbonylation of alkenes by an unprecedented use of methyl formate as a source of both the methoxy and the methoxycarbonyl groups. This reaction transforms styrene and its derivatives into value-added β-methoxy alkanoates and cinnamates, as well as medicinally important five-membered heterocycles, such as functionalized tetrahydrofurans, γ-lactones, and pyrrolidines. A ternary β-diketiminato-CuI-styrene complex, fully characterized by NMR spectroscopy and X-ray crystallographic analysis, is capable of catalyzing the same transformation. These findings suggest that pre-coordination of electron-rich alkenes to copper might play an important role in accelerating the addition of nucleophilic radicals to electron-rich alkenes, and could have general implications in the design of novel radical-based transformations.

Metal-free Deoxygenative 2-Amidation of Quinoline N-oxides with Nitriles via a Radical Activation Pathway

A metal-, base- and reductant-free approach for the efficient synthesis of various N-acylated 2-aminoquinolines was reported. In this work, readily available nitriles are used as the amide source, and methyl carbazate as both the radical activating reagent and oxygen source. This is the first report on the ester-radical-activated highly regioselective addition of nitriles to quinolone N-oxides. This procedure is expected to complement the current methods for functionalization of N-oxides via an electrophilic activation mechanism. (Figure presented.).

Microwave-Assisted Synthesis of Phenylpropanoids and Coumarins: Total Synthesis of Osthol

Herein we describe a one-pot microwave-assisted method for the synthesis of cinnamic acid and coumarin derivatives. The synthesis begins with an aldehyde synthon, and the chosen reaction conditions determine whether a cinnamic acid or coumarin derivative is formed. A regioselective Claisen rearrangement was also efficiently incorporated into the synthetic sequence to further increase the complexity of the product. Notably, this approach provides high product yields and selectivities without the need of a phenol protecting group.

Traceless directing group mediated branched selective alkenylation of unbiased arenes

Owing to the synthetic importance of branched olefinated products, we report palladium catalyzed formation of branched olefins facilitated by a C-H activation based protocol. This involves selective insertion of olefins and subsequent decarboxylation using a completely unbiased benzene ring as the starting precursor. The significance of the protocol has been further highlighted by exhibition of functionality tolerance along with a late-stage modification of the branched olefinated products leading to the formation of other functionalized molecules.

HUSY zeolite promoted hydrophenylation of alkynes conjugated with electron-withdrawing substituents

Arylacetylenes, conjugated with electron-withdrawing groups, ArC[tbnd6]C(EWG) [EWG = SO2Ph, PO(OEt)2, COMe, CO2Me] in reaction with benzene at room temperature or 130?°C (glass high pressure tube) for 1–10?h under the acti