346433-57-6

Basic information

• Product Name: carbonic acid tert-butyl ester 3-hydroxy-4-(3-methyl-but-2-enyl)-phenyl ester
• Synonyms: carbonic acid tert-butyl ester 3-hydroxy-4-(3-methyl-but-2-enyl)-phenyl ester
• CAS NO: 346433-57-6
• Molecular Weight: 278.348
• Mol File: 346433-57-6.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: carbonic acid tert-butyl ester 3-hydroxy-4-(3-methyl-but-2-enyl)-phenyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: carbonic acid tert-butyl ester 3-hydroxy-4-(3-methyl-but-2-enyl)-phenyl ester(346433-57-6)
• EPA Substance Registry System: carbonic acid tert-butyl ester 3-hydroxy-4-(3-methyl-but-2-enyl)-phenyl ester(346433-57-6)

Safety Data

• Hazardous Substances Data: 346433-57-6(Hazardous Substances Data)

Upstream product

• 95-01-2 2,4-Dihydroxybenzaldehyde 
• 288268-32-6 bis-(2,4-tert-butoxycarbonyloxy)-benzaldehyde 
• 24424-99-5 di-tert-butyl dicarbonate 
• 3017-69-4 2-methyl-1-propenylbromide 
• 288268-46-2 1-(hydroxy-methyl)-2,5-di-tert-butoxycarbonyloxy-benzene 
• 38614-36-7 2-methylpropen-1-ylmagnesium bromide 

Downstream Products

• 1310328-58-5 3'-cyanobiphenyl-4-carboxylic acid 3-hydroxy-2,2-dimethylchroman-7-yl ester 
• 1310328-57-4 3'-nitrobiphenyl-4-carboxylic acid 3-hydroxy-2,2-dimethylchroman-7-yl ester 
• 1310328-56-3 3'-methoxybiphenyl-4-carboxylic acid 3-hydroxy-2,2-dimethylchroman-7-yl ester 
• 1310328-55-2 4-bromobenzoic acid 3-hydroxy-2,2-dimethylchroman-7-yl ester 
• 1310328-54-1 3-benzyloxy-benzoic acid 3-hydroxy-2,2-dimethyl-chroman-7-yl ester 
• 1310328-53-0 4-benzyloxybenzoic acid 3-hydroxy-2,2-dimethylchroman-7-yl ester 
• 1310328-52-9 3,4-bis(benzyloxy)benzoic acid 3-hydroxy-2,2-dimethylchroman-7-yl ester 
• 1310328-51-8 3,5-bis(benzyloxy)benzoic acid 3-hydroxy-2,2-dimethylchroman-7-yl ester 
• 1310328-50-7 4-hydroxybenzoic acid 3-hydroxy-2,2-dimethylchroman-7-yl ester 
• 1310328-49-4 3,4-dihydroxybenzoic acid 3-hydroxy-2,2-dimethylchroman-7-yl ester 
• 1310328-43-8 3,5-bis(benzyloxy)benzoic acid 2-(1-hydroxy-1-methylethyl)-2,3-dihydrobenzofuran-6-yl ester 
• 1310328-35-8 2-[6-(3-methoxyphenyl)-2,3-dihydrobenzo[1,2-b;5,4-b']difuran-2-yl]propan-2-ol 
• 1310328-34-7 2-[6-(2-methoxyphenyl)-2,3-dihydrobenzo[1,2-b;5,4-b']difuran-2-yl]propan-2-ol 
• 1310328-33-6 2-[6-(4-benzyloxyphenyl)-2,3-dihydrobenzo[1,2-b;5,4-b']difuran-2-yl]propan-2-ol 

Relevant articles and documents

HIF-1α inhibitors: Synthesis and biological evaluation of novel moracin O and P analogues

The natural products moracins O and P exhibited potent in vitro inhibitory activity against hypoxia-inducible factor (HIF-1), which is a key mediator during adaptation of cancer cells to tumour hypoxia. Systematic variations of the structures of benzofuran type moracins were made and structure-activity relationship analysis showed the importance of the 2-arylbenzofuran ring and the (R)-configuration of the core scaffold. Further evaluation of the representative compound 5 showed its inhibitory effect on HIF-1α protein accumulation and target gene expression under hypoxia.

A mild anionic method for generating o-quinone methides: Facile preparations of ortho-functionalized phenols

A low-temperature method for generating o-quinone methides is described which permits facile introduction of assorted R substituents onto the aryl ring system at low temperature. The method is useful for the efficient preparation of ortho-ring-alkylated phenols.