346433-57-6

Upstream product

• 3017-69-4 2-methyl-1-propenylbromide 
• 288268-46-2 1-(hydroxy-methyl)-2,5-di-tert-butoxycarbonyloxy-benzene 
• 95-01-2 2,4-Dihydroxybenzaldehyde 
• 288268-32-6 bis-(2,4-tert-butoxycarbonyloxy)-benzaldehyde 
• 24424-99-5 di-tert-butyl dicarbonate 
• 38614-36-7 2-methylpropen-1-ylmagnesium bromide 

Downstream Products

• 464920-03-4 carbonic acid tert-butyl ester 4-(3,3-dimethyl-oxiranylmethyl)-3-hydroxy-phenyl ester 
• 1155310-16-9 tert-butyl-3-(benzyloxy)-4-(3-methylbut-2-enyl)phenyl carbonate 
• 1310328-58-5 3'-cyanobiphenyl-4-carboxylic acid 3-hydroxy-2,2-dimethylchroman-7-yl ester 
• 1310328-57-4 3'-nitrobiphenyl-4-carboxylic acid 3-hydroxy-2,2-dimethylchroman-7-yl ester 
• 1310328-56-3 3'-methoxybiphenyl-4-carboxylic acid 3-hydroxy-2,2-dimethylchroman-7-yl ester 
• 1310328-55-2 4-bromobenzoic acid 3-hydroxy-2,2-dimethylchroman-7-yl ester 
• 1310328-54-1 3-benzyloxy-benzoic acid 3-hydroxy-2,2-dimethyl-chroman-7-yl ester 
• 1310328-53-0 4-benzyloxybenzoic acid 3-hydroxy-2,2-dimethylchroman-7-yl ester 
• 1310328-52-9 3,4-bis(benzyloxy)benzoic acid 3-hydroxy-2,2-dimethylchroman-7-yl ester 
• 1310328-51-8 3,5-bis(benzyloxy)benzoic acid 3-hydroxy-2,2-dimethylchroman-7-yl ester 
• 1310328-50-7 4-hydroxybenzoic acid 3-hydroxy-2,2-dimethylchroman-7-yl ester 
• 1310328-49-4 3,4-dihydroxybenzoic acid 3-hydroxy-2,2-dimethylchroman-7-yl ester 
• 1310328-43-8 3,5-bis(benzyloxy)benzoic acid 2-(1-hydroxy-1-methylethyl)-2,3-dihydrobenzofuran-6-yl ester 
• 1310328-35-8 2-[6-(3-methoxyphenyl)-2,3-dihydrobenzo[1,2-b;5,4-b']difuran-2-yl]propan-2-ol 

Relevant academic research and scientific papers

HIF-1α inhibitors: Synthesis and biological evaluation of novel moracin O and P analogues

The natural products moracins O and P exhibited potent in vitro inhibitory activity against hypoxia-inducible factor (HIF-1), which is a key mediator during adaptation of cancer cells to tumour hypoxia. Systematic variations of the structures of benzofuran type moracins were made and structure-activity relationship analysis showed the importance of the 2-arylbenzofuran ring and the (R)-configuration of the core scaffold. Further evaluation of the representative compound 5 showed its inhibitory effect on HIF-1α protein accumulation and target gene expression under hypoxia.

Strategies for the preparation of differentially protected ortho-prenylated phenols

A new process for ortho-prenylation of phenols is presented within the context of known methods. All of the processes are briefly assessed with regards to the substitution patterns and accompanying functional groups tolerated by each strategy. The conclus

A mild anionic method for generating o-quinone methides: Facile preparations of ortho-functionalized phenols

A low-temperature method for generating o-quinone methides is described which permits facile introduction of assorted R substituents onto the aryl ring system at low temperature. The method is useful for the efficient preparation of ortho-ring-alkylated phenols.