3469-63-4

Usage

Uses

Given the lack of specific information on the uses of ETHYL 5-METHOXY-1H-PYRROLO[2, 3-C]PYRIDINE-2-CARBOXYLATE in the provided materials, it is not possible to list its applications in various industries or for specific purposes. Further research and data would be required to determine its practical applications and the reasons for its use in different fields.

Upstream product

• 6635-90-1 2-Methoxy-4-methyl-5-nitropyridine 
• 23056-33-9 2-chloro-4-methyl-5-nitro-pyridine 
• 3469-62-3 ethyl 3-(2-methoxy-5-nitropyridin-4-yl)-2-oxopropanoate 

Downstream Products

• 1205747-85-8 2-Benzyl-8-methoxy-2,3,10,10a-tetrahydropyrido[4',3':4,5]pyrrolo[1,2-a]-pyrazine-1,4-dione 
• 1205747-88-1 Methyl 2-benzyl-1,2,3,4,10,10a-hexahydropyrido[4',3':4,5]pyrrolo[1,2-a]-pyrazine-8-carboxylate 
• 1205747-90-5 Methyl 2-[(4'-chloro[1,1'-biphenyl]-2-yl)methyl]-1,2,3,4,10,10a-hexahydropyrido[4',3':4,5]pyrrolo[1,2-a]pyrazine-8-carboxylate 
• 1205748-13-5 N-({2-[(4'-Chloro[1,1'-biphenyl]-2-yl)methyl]-1,2,3,4,10,10a-hexahydropyrido[4',3':4,5]pyrrolo[1,2-a]pyrazin-8-yl}carbonyl)-4-({(1R)-3-(dimethyl-amino)-1-[(phenylsulphanyl)methyl]propyl}amino)-3-nitrobenzene-sulphonamide 
• 1205747-86-9 2-benzyl-8-methoxy-1,2,3,4,10,10a-hexahydropyrido[4',3':4,5]pyrrolo-[1,2-a]pyrazine 
• 17288-43-6 (5-methoxy-1H-pyrrolo[2,3-c]pyridin-2-yl)methanol 
• 17288-36-7 5-methoxy-1H-pyrrolo[2,3-c]pyridine-2-carboxylic acid 

Relevant academic research and scientific papers

Polycyclic compound for inhibiting RNA helicase DHX33

The invention relates to a polycyclic compound for inhibiting RNA helicase DHX33. In particular, the invention relates to a compound shown as a formula I or a pharmaceutically acceptable form thereof, a pharmaceutical composition containing the compound, a preparation method of the compound, and medical application of the compound to prevention and/or treatment of DHX33 related diseases.

Synthesis of the new ring system bispyrido[4',3':4,5]pyrrolo [1,2-a:1',2'-d]pyrazine and its deaza analogue

Derivatives of the new ring systems bispyrido[4',3':4,5]pyrrolo[1,2-a:1',2'-d] pyrazine-6,13-dione and its deaza analogue pyrido[4",3":4',5']pyrrolo-[1',2':4,5]pyrazino [1,2-a]indole-6,13-dione were conveniently synthesized through a four-step sequence. Symmetrical derivatives of the former ring system were obtained through self condensation. On the other hand, condensation of 6-azaindole carboxylic acid with indole 2-carboxylic acid afforded the deaza analogue ring system. Derivatives of the title ring system were tested by the National Cancer Institute (Bethesda, MD, USA) and four of them exhibited modest activity against MCF7 (a breast cancer cell line) and/or UO-31 (a renal cancer cell line).

TRICYCLIC COMPOUNDS, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM.

Compounds of formula (I): wherein: A represents a 5, 6 or 7-membered (hetero)aromatic or non-aromatic ring,Z1, Z2 and Z3 each independently of the others represents a CH group or a nitrogen atom, it being understood that at least one of these three groups is a nitrogen atom,X represents an alkylene chain as defined in the description,R2 represents an aryl or heteroaryl group,the group R1 represents a group of formula (II) as defined in the description Medicinal products containing the same which are useful in treating conditions involving a defect in apoptosis.