34753-27-0

Usage

Uses

Used in Pharmaceutical Industry:
6-PHENYL-3(2H)-PYRIDAZINONE-4-CARBOXYLIC ACID ETHYL ESTER is used as a reactant for the chlorination and amidation of 3-?aminopyridazine derivatives. These derivatives possess atypical antidepressant, serotonergic, and dopaminergic activity, making them valuable in the development of novel treatments for various mental health disorders.

InChI:InChI=1/C13H12N2O3/c1-2-18-13(17)10-8-11(14-15-12(10)16)9-6-4-3-5-7-9/h3-8H,2H2,1H3,(H,15,16)

Upstream product

• 94011-50-4 ethyl 3-oxo-6-phenyl-2,3,4,5-tetrahydropyridazine-4-carboxylate 
• 3709-20-4 dimethyl 2-phenyl-1,1-cyclopropanedicarboxylate 
• 105-53-3 diethyl malonate 
• 70-11-1 α-bromoacetophenone 
• 94011-49-1 diethyl phenacylmalonate 
• 80989-82-8 diethyl 2-hydroxy-2-(2-oxo-2-phenylethyl)malonate 

Downstream Products

• 404933-59-1 4-(4-morpholinoethylaminocarbonyl)-6-phenyl-3-(2H)-pyridazinone hydrochloride 
• 89868-06-4 4-amino-6-phenyl-3(2H)-pyridazinone 
• 94011-81-1 3-(2-morpholinoethylamino)-4-cyano-6-phenylpyridazine dihydrochloride 
• 94011-64-0 3-chloro-6-phenylpyridazine-4-carbonitrile 

Relevant academic research and scientific papers

Design, synthesis and bioevaluation of 3-oxo-6-aryl-2,3-dihydropyridazine-4-carbohydrazide derivatives as novel xanthine oxidase inhibitors

In view of expanding the structure activity relationship of xanthine oxidase inhibitors, a series of 3-oxo-6-aryl-2,3-dihydropyridazine-4-carbohydrazide/carboxylic acid derivatives were designed by molecular docking and synthesized. All the target compoun

Electrocatalytic Activation of Donor–Acceptor Cyclopropanes and Cyclobutanes: An Alternative C(sp3)?C(sp3) Cleavage Mode

We describe the first electrochemical activation of D–A cyclopropanes and D–A cyclobutanes leading after C(sp3)?C(sp3) cleavage to the formation of highly reactive radical cations. This concept is utilized to formally insert molecula

New pyridazinone-4-carboxamides as new cannabinoid receptor type-2 inverse agonists: Synthesis, pharmacological data and molecular docking

In the last few years, cannabinoid type-2 receptor (CB2R) selective ligands have shown a great potential as novel therapeutic drugs in several diseases. With the aim of discovering new selective cannabinoid ligands, a series of pyridazinone-4-c

Synthesis of pyridazine acetic acid derivatives possessing aldose reductase inhibitory activity and antioxidant properties

N-Acetic acid derivatives of 4-carboxy-6-arylpyridazin-3-ones were synthesized for the dual purpose of inhibiting aldose reductase and exhibiting antioxidant properties. All the prepared compounds showed a significant in vitro aldose reductase inhibitory

3-Aminopyridazine derivatives with atypical antidepressant, serotonergic, and dopaminergic activities

Minaprine [3[(β-morpholinoethyl)amino]4-methyl-6-phenylpyridazine dihydrochloride] is active in most animal models of depression and exhibits in vivo a dual dopaminomimetic and serotoninomimetic activity profile. In an attempt to dissociate these two effe