34784-06-0 Usage
Uses
Used in Pharmaceutical Industry:
7-Chloroisoquinoline is used as a key intermediate in the synthesis of 1H-1,2,3-triazole-5-carboxylic acid derivatives. These derivatives have been identified as glycolate oxidase inhibitors, which are important for the treatment of hyperoxaluria and related diseases. By inhibiting glycolate oxidase, these derivatives can help regulate the metabolic pathways and reduce the formation of oxalate, thereby alleviating the symptoms and complications associated with hyperoxaluria.
Check Digit Verification of cas no
The CAS Registry Mumber 34784-06-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,4,7,8 and 4 respectively; the second part has 2 digits, 0 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 34784-06:
(7*3)+(6*4)+(5*7)+(4*8)+(3*4)+(2*0)+(1*6)=130
130 % 10 = 0
So 34784-06-0 is a valid CAS Registry Number.
InChI:InChI=1/C9H6ClN/c10-9-2-1-7-3-4-11-6-8(7)5-9/h1-6H
34784-06-0Relevant academic research and scientific papers
Synthesis of Indole-Dihydroisoquinoline Sulfonyl Ureas via Three-Component Reactions
Pearson, Stuart E.,Fillery, Shaun M.,Goldberg, Kristin,Demeritt, Julie E.,Eden, Jonathan,Finlayson, Jonathan,Patel, Anil
, p. 4963 - 4981 (2018/12/13)
Isoquinolines activated with sulfamoyl chlorides were reacted with indoles in a 3-component reaction to generate a library of dihydroisoquinoline derivatives. Using a differential protecting group strategy, products could be further derivatised. Synthesis of isoquinoline starting materials using several different methods is also described.
Inhibitors of checkpoint kinases
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Page/Page column 29; 30, (2008/06/13)
The instant invention provides for compounds which comprise substituted triazoloquinazolinones that inhibit CHK1 activity. The invention also provides for compositions comprising such inhibitory compounds and methods of inhibiting CHK1 activity by adminis
