34786-24-8

Usage

Physical state

Colorless liquid

Odor

Strong, sweet

Solubility

Insoluble in water

Uses

a. Flavoring agent in the food industry
b. Fragrance ingredient in the perfume industry
c. Intermediate in the synthesis of pharmaceuticals and agrochemicals
d. Production of dyes, polymers, and other industrial applications

Safety precautions

a. Harmful if swallowed or inhaled
b. May cause skin irritation upon contact
c. Handle with care

InChI:InChI=1/C9H12S/c1-3-10-9-6-4-5-8(2)7-9/h4-7H,3H2,1-2H3

Upstream product

• 46185-83-5 2-ethoxyquinoline 
• 108-40-7 toluene-3-thiol 
• 4886-77-5 3-methylthioanisole 
• 74-88-4 methyl iodide 
• 75-03-6 ethyl iodide 
• 118736-37-1 1,1-bis(benzenesulphonyl)-5-(3-methylbenzenethio)pentane 
• 118736-23-5 1,1-bis(benzenesulphonyl)-3-(3-methylbenzenethio)propane 
• 118736-22-4 1-iodo-2-(3-methylbenzenethio)ethane 
• 16798-92-8 (2-chloroethyl)(3-methylphenyl)sulfane 
• 33733-73-2 3-bromo-1-(methylthio)benzene 
• 74-96-4 ethyl bromide 
• 118736-32-6 1,1-bis(benzenesulphonyl)-4-(3-methylbenzenethio)butane 

Downstream Products

• 74-85-1 ethene 
• 13865-48-0 3-methylphenyl phenyl sulfide 
• 121034-20-6 C₉H₁₃NOS 
• 777943-99-4 1-bromo-4-ethanesulfanyl-2-methyl benzene 
• 107100-54-9 (4-ethylsulfanyl-2-methyl-phenyl)-phenyl-diazene 

Relevant academic research and scientific papers

NAPHTHYLACETIC ACIDS

The invention is concerned with the compounds of formula (I) and pharmaceutically acceptable salts and esters thereof, wherein X, Q, and R1-R6 are defined in the detailed description and claims. In addition, the present invention relates to methods of manufacturing and using the compounds of formula (I) as well as pharmaceutical compositions containing such compounds. The compounds of formula (I) are antagonists or partial agonists at the CRTH2 receptor and may be useful in treating diseases and disorders associated with that receptor such as asthma.

Metallation reactions. Part 35: A change of the regiochemistry in the metallation of (alkylthio)arenes

The metallation reaction of bromo(alkylthio)benzenes is described. The results show the complementarity of these reactions with the metal-hydrogen exchange reaction. In fact, monometallation of bromo(methylthio)benzenes afforded products substituted in para or meta or ortho to the thioethereal function while bimetallation led to αS,para, αS,meta and αS,ortho disubstituted products. Analogously, the monometallation of 4-bromo-(isopropylthio)benzene afforded para-monosubstituted and ortho,para-disubstituted products.

Metallation reactions. XXI. Metallation of alkyl (alkylthio) benzenes by superbases versus organolithium compounds

The metallation regiochemistry of alkyl(alkylthio)benzenes with butyllithium or with the superbasic mixture of butyllithium with potassium tert-butoxide is described. The reaction pattern depends on the substrate and the reagent. Butyllithium monometallates the thiomethylic carbon of methyl (methylthio) benzenes and bimetallates the thiomethylic and the annular carbon ortho to the thioethereal group. With superbases the metallation occurs at the thiomethylic and methylic carbon. Metallation with butyllithium of the higher homologs substitutes exclusively the hydrogen ortho to the thioalkylic group, while the superbases attack also the carbon atom alpha to the thioalkyl substituent.

TRANSITION STATES IN INTRAMOLECULAR SN2 REACTIONS OF CARBANIONS. THE CLOSURE OF THREE-, FOUR- AND FIVE-MEMBERED RINGS

The intramolecular displacement of aryl ethyl sulphonium by carbanions stabilised by two sulphonyl groups has been studied.Rates of cyclisation of three-, four- and five-membered rings follow the same trend observed in the analogous displacement of halides.The effects of substituents on the leaving group show that, in the series considered, variations in the extent of bond cleavage to the leaving group are small.

PREPARATION OF PHENYL ARYL SULFIDES BY REACTION OF BENZYNE WITH ETHYL ARYL SULFIDES

A variety of ethyl aryl sulfides (1) react with benzyne, with evolution of ethylene, to give phenyl aryl sulfides (3) in excellent yields, thus providing a general synthesis of 3 from arenethiols since 1 are quantitatively obtainable from arenethiols and ethyl bromide.