3480-56-6Relevant academic research and scientific papers
Palladium-catalyzed oxidative amination of alkenes: Improved catalyst reoxidation enables the use of alkene as the limiting reagent
Rogers, Michelle M.,Kotov, Vasily,Chatwichien, Jaruwan,Stahl, Shannon S.
, p. 4331 - 4334 (2007)
Palladium-catalyzed methods for intermolecular aerobic oxidative amination of alkenes have been identified that are compatible with the use of alkene as the limiting reagent. These procedures, which enhance the utility of this reaction with alkenes that a
Palladium-catalyzed vicinal difunctionalization of internal alkenes: Diastereoselective synthesis of diamines
Martinez, Claudio,Muniz, Kilian
supporting information; scheme or table, p. 7031 - 7034 (2012/09/25)
Internal affairs: The first general palladium-catalyzed intermolecular diamination of internal alkenes employs different nitrogen sources, which add to the alkene in a regio- and diastereoselective fashion. The resulting diamination products can be converted directly into a known ligand motif. Copyright
Aerobic oxidative amination of unactivated alkenes catalyzed by palladium
Brice, Jodie L.,Harang, Jenna E.,Timokhin, Vitaliy I.,Anastasi, Natia R.,Stahl, Shannon S.
, p. 2868 - 2869 (2007/10/03)
The first examples of palladium-catalyzed oxidative amination of unactivated alkyl olefins have been identified. To be successful, these reactions must be conducted under cocatalyst-free conditions that involve direct dioxygen-coupled turnover of the palladium catalyst. The oxidative amination products of norbornene and other cyclic alkenes implicate a cis-aminopalladation mechanism. Copyright
A Convenient Method for the Synthesis of α-Imidostyrenes from Styrenes and Imides via Diphenylstyrylsulfonium Salts
Yamanaka, Hiroyuki,Mukaiyama, Teruaki
, p. 1192 - 1193 (2007/10/03)
Styrenes having a hydrogen atom at the α-position reacted with diphenyl(trifluoromethanesulfonyloxy)sulfonium triflate (1) to form diphenylstyrylsulfonium triflates 2 that were in turn converted into the corresponding α-imidostyrenes on treatment with sodium or potassium salts of cyclic imides.
Dioxygen-Coupled Oxidative Amination of Styrene
Timokhin, Vitaliy I.,Anastasi, Natia R.,Stahl, Shannon S.
, p. 12996 - 12997 (2007/10/03)
Dioxygen-coupled oxidative amination of olefins is an attractive, but challenging, catalytic transformation. The present work describes the first general method for intermolecular oxidative amination of aryl olefins with molecular oxygen as the stoichiometric oxidant. This palladium-catalyzed reactivity is compatible with several different nitrogen nucleophiles, including oxazolidinone, phthalimide, pyrrolidinone, and p-toluenesulfonamide. The presence of a catalytic quantity of a Bronsted base in the reaction increases the catalytic activity and switches the reaction regioselectivity. Copyright
Aminotetralone Analogues of Ketamine: Synthesis and Evaluation of Hypnotic and Locomotor Properties in Mice
Yang, David J.,Davisson, John N.
, p. 1361 - 1365 (2007/10/02)
Ketamine and phencyclidine are structurally similar compounds that share many pharmacological actions, some of which are similar to the phenethylamines amphetamine and cathione.In order to integrate structural features of ketamine and cathinone, two groups of analogues, which are more conformationally restricted compared to the parent compounds, were synthesized for biological evaluation.These included 1-amino-1-methyl-2-tetralone and 2-amino-2-methyl-1-tetralone was well as several N-substituted derivatives of these molecules.Locomotor activity testing in mice revealed that 2-amino-2-methyl-1-tetralone caused an increase in locomotor activity while 1-amino-1-methyl-2-tetralone depressed soontaneous locomotor activity.None of the compounds produced hypnosis or profound ataxia.
