83256-46-6Relevant academic research and scientific papers
Synthesis, anti-inflammatory, cytotoxic, and COX-1/2 inhibitory activities of cyclic imides bearing 3-benzenesulfonamide, oxime, and β-phenylalanine scaffolds: a molecular docking study
Abdel-Aziz, Alaa A.-M.,El-Azab, Adel S.,AlSaif, Nawaf A.,Alanazi, Mohammed M.,El-Gendy, Manal A.,Obaidullah, Ahmad J.,Alkahtani, Hamad M.,Almehizia, Abdulrahman A.,Al-Suwaidan, Ibrahim A.
, p. 610 - 621 (2020/02/15)
Cyclic imides containing 3-benzenesulfonamide, oxime, and β-phenylalanine derivatives were synthesised and evaluated to elucidate their in?vivo anti-inflammatory and ulcerogenic activity and in?vitro cytotoxic effects. Most active anti-inflammatory agents
Regioselective β-Csp3-Arylation of β-Alanine: An Approach for the Exclusive Synthesis of Diverse β-Aryl-β-amino Acids
Chowdhury, Sushobhan,Vaishnav, Roopal,Panwar, Namita,Haq, Wahajul
, p. 2512 - 2522 (2019/03/07)
An approach for the synthesis of a variety of new β-aryl-β-amino acids has been developed via a palladium-catalyzed auxiliary-directed regioselective Csp3-H arylation of the unactivated β-methylene bond of β-alanine. The use of 8-aminoquinoline amide as an auxiliary efficiently directs the desired regioselective β-Csp3-H functionalization. The developed protocol enables the easy and straightforward access to several high-value β-aryl-β-amino acids useful for peptide engineering, starting from inexpensive and readily available β-alanine precursors in moderate to excellent yields.
A facile approach to β-amino acid derivatives via palladium-catalyzed hydrocarboxylation of enimides with formic acid
Dai, Jie,Ren, Wenlong,Wang, Haining,Shi, Yian
supporting information, p. 8429 - 8432 (2015/08/06)
An effective Pd(0)-catalyzed hydrocarboxylation of enimides with formic acid in the presence of a catalytic amount of HCOOPh is described. A variety of β-amino acid derivatives are obtained in good yields with high regioselectivities without using external toxic CO gas.
Palladium-catalyzed intermolecular aminocarbonylation of alkenes: Efficient access of β-amino acid derivatives
Cheng, Jiashun,Qi, Xiaoxu,Li, Ming,Chen, Pinhong,Liu, Guosheng
supporting information, p. 2480 - 2483 (2015/03/04)
A novel palladium-catalyzed intermolecular aminocarbonylation of alkenes has been developed in which the employment of hypervalent iodine reagent can accelerate the intermolecular aminopalladation, which thus provides the successful catalytic transformation. The current transformation presents one of the most convenient methods to generate β-amino acid derivatives from simple alkenes.
