34849-19-9

Usage

Uses

Used in Pharmaceutical Synthesis:
1,2,3,4-TETRAHYDRO-QUINOLINE-8-CARBOXYLIC ACID is used as a building block for the synthesis of various pharmaceuticals and organic compounds. Its unique structure and functional groups make it a versatile component in the development of new drugs and therapeutic agents.
Used in Medicinal Chemistry Research:
In the field of medicinal chemistry, 1,2,3,4-TETRAHYDRO-QUINOLINE-8-CARBOXYLIC ACID is utilized as a key intermediate in the production of pharmaceuticals. Its potential pharmacological properties are being studied to explore its use in the treatment of various medical conditions, making it a promising candidate for further research and development.
Used in Drug Development:
1,2,3,4-TETRAHYDRO-QUINOLINE-8-CARBOXYLIC ACID is employed as a precursor in the development of new drugs. Its chemical properties and structural features allow for the creation of novel compounds with potential therapeutic effects, contributing to the advancement of pharmaceutical innovation.
Overall, 1,2,3,4-TETRAHYDRO-QUINOLINE-8-CARBOXYLIC ACID is a crucial component in the pharmaceutical and medicinal chemistry industries, with its applications spanning from drug synthesis to research and development of new therapeutic agents.

InChI:InChI=1/C10H11NO2/c12-10(13)8-5-1-3-7-4-2-6-11-9(7)8/h1,3,5,11H,2,4,6H2,(H,12,13)

Upstream product

• 86-59-9 8-carboxyquinoline 
• 118-92-3 anthranilic acid 

Downstream Products

• 118128-79-3 ethyl ester of 1,2,3,4-tetrahydroquinoline-8-carboxylic acid 
• 635-46-1 1,2,3,4-tetrahydroisoquinoline 

Relevant academic research and scientific papers

PLANT GROWTH REGULATOR

PROBLEM TO BE SOLVED: To provide a plant growth regulator. SOLUTION: The plant growth regulator comprises a compound represented by general formula 1, or a salt or ester thereof. [In the formula, (A1-A2-A3-A4) is (N=CH-CH=CH) or (NH-CH2-CH2-CH2); R1 and R2 are each independently H, an alkyl group or a halogen atom; and R3 is a hydroxyl group or an alkoxy group.] SELECTED DRAWING: None COPYRIGHT: (C)2018,JPO&INPIT

Heterocyclic-esters or -amides used as 5-HT4 receptor antagonists

Compounds of formula (I), wherein formula I consists of formulae (I-1) to (I-4), which are defined in the specification, and pharmaceutically acceptable salts thereof, and the use of a compound of formula I or a pharmaceutically acceptable salt thereof, and their use as pharmaceuticals in the treatment of gastrointestinal disorders, cardiovascular disorders and CNS disorder.

Synthesis and evaluation of heterocyclic carboxamides as potential antipsychotic agents

Heterocyclic analogues of 1192U90, 2-amino-N-(4-(4-(1,2-benzisothiazol- 3-yl)-1-piperazinyl)-butyl)benzamide hydrochloride (1), were prepared and evaluated as potential antipsychotic agents. These analogues were evaluated in vitro for their binding to the dopamine D2, serotonin 5-HT2, and serotonin 5-HT(1a) receptors and in vivo for their ability to antagonize the apomorphine-induced climbing response in mice. Nine different types of heterocyclic carboxamides were studied in this investigation (i.e., pyridine- , thiophene-, benzothiophene-, quinoline-, 1,2,3,4-tetrahydroquinoline-, 2,3- dihydroindole-, indole-, benzimidazole-, and indazolecarbox-amides). Two derivatives exhibited potent in vivo activities comparable to 1: 3-amino-N- (4(4-(1,2-benzisothiazol-3-yl)-1-piperazinyl)butyl)-2-pyridinecarboxamide (16) and 3-amino-N-(4(4-(1,2-benzisothiazol-3-yl)-1-piperazinyl)butyl)-2- thiophenecarboxamide (29). Furthermore, these derivatives were found to be much less active in behavioral models predictive of extrapyramidal side effects than in the mouse climbing assay, which predicts antipsychotic activity. Carboxamides 16 and 29 were selected for further evaluation as potential backup compounds to 1.

Reduction of Quinolinecarboxylic Acids by Raney Alloy

The heterocyclic nucleus in quinolinecarboxylic acids is reduced by Raney alloy (nickel-aluminium) in alkaline media to give 1,2,3,4-tetrahydro-2-,3-,4-,5-,6-, and 8-quinolinecarboxylic acids and 8-methyl-5-quinolinecarboxylic acid and their ethyl esters.