402-07-3

Basic information

• Product Name: 4-BROMO-3-METHOXYBENZOTRIFLUORIDE
• Synonyms: 1-Bromo-2-methoxy-4-(trifluoromethyl)benzene, 2-Bromo-5-(trifluoromethyl)phenyl methyl ether;4-Bromo-3-methoxybenzotrifluoride 98%;4-BROMO-3-METHOXYBENZOTRIFLUORIDE;1-Bromo-2-methoxy-4-(trifluoromethyl)benzene;2-Bromo-5-(Trifluoromethyl)anisole
• CAS NO: 402-07-3
• Molecular Formula: C₈H₆BrF₃O
• Molecular Weight: 255.03
• Mol File: 402-07-3.mol
• Article Data: 2

Chemical Properties

• Melting Point: 36.5 °C
• Boiling Point: 225℃
• Flash Point: 109℃
• Appearance: /
• Density: 1.563
• Vapor Pressure: 0.134mmHg at 25°C
• Refractive Index: 1.471
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 4-BROMO-3-METHOXYBENZOTRIFLUORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-BROMO-3-METHOXYBENZOTRIFLUORIDE(402-07-3)
• EPA Substance Registry System: 4-BROMO-3-METHOXYBENZOTRIFLUORIDE(402-07-3)

Safety Data

• Hazard Codes: T
• Hazardous Substances Data: 402-07-3(Hazardous Substances Data)

Usage

Chemical Properties

light yellow liquid

InChI:InChI=1/C8H6BrF3O/c1-13-7-4-5(8(10,11)12)2-3-6(7)9/h2-4H,1H3

Upstream product

• 40161-54-4 1-bromo-2-fluoro-4-(trifluoromethyl)benzene 
• 124-41-4 sodium methylate 
• 402-05-1 2-bromo-5-(trifluoromethyl)phenol 
• 74-88-4 methyl iodide 
• 77-78-1 dimethyl sulfate 

Downstream Products

• 1449700-72-4 chloro-di(4-trifluoromethyl-2-methoxy-phenyl)phosphine 
• 1449700-76-8 lithium-2-(di-(4-trifluormethyl-2-methoxy-phenyl)phosphine)benzenesulfonate 
• 1449700-83-7 2-(di(-4-trifluormethyl-2-methoxy-phenyl)phosphine)benzenesulfonic acid 
• 1449700-86-0 bis{N,N’-{(κ2-P,O)-2-[di-(2-methoxy-4-trifluoromethyl-phenyl)-phosphine]benzenesulfonate} palladium(II)-methyl}-N,N,N’,N’-tetramethylethylenediamine 
• 1429027-74-6 2-(benzyloxy)-1-bromo-4-(trifluoromethyl)benzene 
• 1450924-20-5 3-hydroxy-4-((2-methoxy-4-(trifluoromethyl)phenyl)amino)-N-(4-methoxybenzyl)-N-(thiazol-2-yl)benzenesulfonamide 
• 1450922-23-2 4-(2-methoxy-4-(trifluoromethyl)phenyl)-N-(thiazol-2-yl)-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonamide 
• 349-55-3 5-(trifluoromethyl)-m-anisidine 
• 448-36-2 2-methoxy-4-(trifluoromethyl)-benzoic acid 

Relevant articles and documents

Strong Short-Range Cooperativity in Hydrogen-Bond Chains

Chains of hydrogen bonds such as those found in water and proteins are often presumed to be more stable than the sum of the individual H bonds. However, the energetics of cooperativity are complicated by solvent effects and the dynamics of intermolecular interactions, meaning that information on cooperativity typically is derived from theory or indirect structural data. Herein, we present direct measurements of energetic cooperativity in an experimental system in which the geometry and the number of H bonds in a chain were systematically controlled. Strikingly, we found that adding a second H-bond donor to form a chain can almost double the strength of the terminal H bond, while further extensions have little effect. The experimental observations add weight to computations which have suggested that strong, but short-range cooperative effects may occur in H-bond chains.