68120-60-5

Basic information

• Product Name: (R)-[3,5-bis(trifluoromethyl)phenyl]ethanol
• Synonyms: (R)-[3,5-bis(trifluoromethyl)phenyl]ethanol
• CAS NO: 68120-60-5
• Molecular Weight: 258.163
• Mol File: 68120-60-5.mol
• Article Data: 153

Chemical Properties

• CAS DataBase Reference: (R)-[3,5-bis(trifluoromethyl)phenyl]ethanol(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-[3,5-bis(trifluoromethyl)phenyl]ethanol(68120-60-5)
• EPA Substance Registry System: (R)-[3,5-bis(trifluoromethyl)phenyl]ethanol(68120-60-5)

Safety Data

• Hazardous Substances Data: 68120-60-5(Hazardous Substances Data)

Upstream product

• 328-70-1 3,6-bis(trifluoromethyl)bromobenzene 
• 75-07-0 acetaldehyde 
• 30071-93-3 3,5-bis(trifluoromethyl)phenyl methyl ketone 
• 69638-96-6 isopropenyl valerate 
• 68120-60-5 1-(3,5-bis(trifluoromethyl)phenyl)ethan-1-ol 
• 534613-13-3 (R)-O-acetyl-1-(3,5-bis(trifluoromethyl)phenyl)ethanol 
• 225920-05-8 (S)-3,5-bis(trifluoromethyl)-1-phenylethanol 
• 108-22-5 Isopropenyl acetate 
• 123-62-6 propionic acid anhydride 
• 22348-32-9 (S)-diphenylprolinol 
• 7480-35-5 (1S,2R)-1-amino-2-indanol 
• 141550-15-4 (R,R)-1,2-dicyclohexylethanediol (S)-(1-chloroethyl)boronate 
• 108-05-4 vinyl acetate 
• 349-59-7 3,5-bis(trifluoromethyl)styrene 

Downstream Products

• 30071-93-3 3,5-bis(trifluoromethyl)phenyl methyl ketone 
• 225920-05-8 (S)-3,5-bis(trifluoromethyl)-1-phenylethanol 
• 368-63-8 (R)-[3,5-bis(trifluoromethyl)phenyl]ethanol 
• 534613-13-3 (R)-O-acetyl-1-(3,5-bis(trifluoromethyl)phenyl)ethanol 
• 1007592-45-1 C₁₇H₁₆F₆O₃ 
• 1007592-12-2 C₁₇H₁₆F₆O₂ 
• 287930-75-0 (2R,2αR)-4-benzyl-2-[1-[3,5-bis(trifluoromethyl)phenyl]]ethoxy-morpholin-3-one 
• 629956-21-4 1-(3,5-bistrifluoromethylphenyl)ethyl imidazole-1-carboxylate 
• 367922-41-6 methanesulfonic acid (S)-1-(3,5-bis(trifluoromethyl)phenyl)ethyl ester 
• 892868-64-3 [(3R,4R,5R,6R)-4-[(benzyloxy)methyl]-6-{(1R)-1-[3,5-bis(trifluoromethyl)phenyl]-ethoxy}-5-(4-fluorophenyl)tetrahydro-2H-pyran-3-yl]methyl 4-nitrobenzoate 
• 1360454-52-9 (S)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl propanoate 
• 127733-40-8 (S)-α-(3,5-bis(trifluoromethyl)phenyl)ethylamine 
• 892868-78-9 [(3R,4R,5R,6R)-4-[(benzyloxy)methyl]-6-{(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy}-5-(4-fluoro-2-methylphenyl)tetrahydro-2H-pyran-3-yl]methyl 4-nitrobenzoate 
• 160376-84-1 1-[3,5-bis(trifluoromethyl)phenyl]ethyl bromide 

Relevant articles and documents

Mn(i) phosphine-amino-phosphinites: a highly modular class of pincer complexes for enantioselective transfer hydrogenation of aryl-alkyl ketones

A series of Mn(i) catalysts with readily accessible and more π-accepting phosphine-amino-phosphinite (P′(O)N(H)P) pincer ligands have been explored for the asymmetric transfer hydrogenation of aryl-alkyl ketones which led to good to high enantioselectivities (up to 98%) compared to other reported Mn-based catalysts for such reactions. The easy tunability of the chiral backbone and the phosphine moieties makes P′(O)N(H)P an alternative ligand framework to the well-known PNP-type pincers.

Method for refining chiral alcohol

The invention relates to a method for refining chiral alcohol shown as a formula (I). The method comprises the following steps: providing a crude product of the chiral alcohol shown as the formula (I); refining the crude product of chiral alcohol shown in the formula (I) by adopting a refining solvent to prepare a refined product of chiral alcohol shown in the formula (I); wherein the refining solvent is selected from at least one of diethyl ether, n-heptane, methyl tert-butyl ether and isopropyl ether; according to the refining method of the chiral alcohol, on the basis of ensuring the yield of the chiral alcohol, the residual quantity of process impurities can be controlled to be below 0.3%. The refining method is simple, special instruments and equipment are not needed, special operation skills are also not needed, and therefore the refining method is particularly suitable for industrial production and application.

A Cobalt(II) Complex Bearing the Amine(imine)diphosphine PN(H)NP Ligand for Asymmetric Transfer Hydrogenation of Ketones

Novel chiral cobalt complex a containing amine(imine)diphosphine PN(H)NP ligand and complex b containing bis(amine)diphosphine PN(H)N(H)P ligand were synthesized. The structures of two complexes were characterized by X-ray crystallography and high resolution mass spectrometry. The catalytic performances of cobalt complexes a and b for asymmetric transfer hydrogenation (ATH) of ketones under mild conditions were evaluated using 2-propanolisopropanol as solvent and hydrogen source after being activated by 8 equivalents of base. Complex a showed a good reactivity for reduction of ketones, with a turnover number (TON) of up to 555, and a maximum enantiomeric excess (ee) value of up to 91 %. Complex b exhibited inertness for hydrogenation of ketones. Electronic structure studies on a and b were conducted to account for the function of ligands on the catalytic performances.