350-10-7

Basic information

• Product Name: N-(trifluoroacetyl)tyrosine
• CAS NO: 350-10-7
• Molecular Formula: C₁₁H₁₀F₃NO₄
• Molecular Weight: 277.1966
• Mol File: 350-10-7.mol

Chemical Properties

• Boiling Point: 466.6°C at 760 mmHg
• Flash Point: 236°C
• Density: 1.478g/cm³
• Vapor Pressure: 1.66E-09mmHg at 25°C
• Refractive Index: 1.521
• CAS DataBase Reference: N-(trifluoroacetyl)tyrosine(CAS DataBase Reference)
• NIST Chemistry Reference: N-(trifluoroacetyl)tyrosine(350-10-7)
• EPA Substance Registry System: N-(trifluoroacetyl)tyrosine(350-10-7)

Safety Data

• Hazardous Substances Data: 350-10-7(Hazardous Substances Data)

Usage

Uses

Used in Analytical Chemistry:
N-(trifluoroacetyl)tyrosine is used as a standard for its unique properties that facilitate detection and quantification in analytical techniques such as liquid chromatography and mass spectrometry.
Used in Organic Synthesis:
In the realm of organic synthesis, N-(trifluoroacetyl)tyrosine serves as a versatile reagent, contributing to the creation of a wide range of chemical compounds.
Used in Pharmaceutical Research and Development:
N-(trifluoroacetyl)tyrosine is utilized in the research and development of pharmaceuticals, where its modified structure can be key in the design and synthesis of new drug candidates.
Used in Agrochemical Research and Development:
N-(trifluoroacetyl)tyrosine also plays a role in agrochemical research and development, potentially leading to advancements in pesticides, herbicides, and other agricultural products.
Overall, N-(trifluoroacetyl)tyrosine is an important compound in the fields of chemistry and biotechnology, with applications spanning across various industries.

Upstream product

• 3799-87-9 methyl (2,2,2-trifluoroacetyl)-L-tyrosinate 
• 354-32-5 trifluoracetyl chloride 
• 60-18-4 L-tyrosine 
• 383-63-1 ethyl trifluoroacetate, 
• 758-42-9 1,1,1-trichloro-3,3,3-trifluoro-propan-2-one 
• 407-25-0 trifluoroacetic anhydride 
• 76-05-1 trifluoroacetic acid 

Downstream Products

• 3870-24-4 N-(O-benzyl-N-trifluoroacetyl-DL-seryl)-L-tyrosine-(N'-trityl-hydrazide) 
• 3799-87-9 methyl (2,2,2-trifluoroacetyl)-L-tyrosinate 
• 467-27-6 N-trifluoroacetyl-L-tyrosine-(N'-trityl-hydrazide) 

Relevant articles and documents

TFA-protected α-amino acid N-hydroxysuccinimide ester: Application for inter- And intramolecular acylation

The utilization of N-trifluoroacetyl (TFA)-α-amino acid N-hydroxysuccinimide ester (OSu) derivatives, a promising acylating agent with high storage stability, is reported for Friedel-Crafts acylation into arenes and N-heterocycles. The reaction between TF

Use of N-trifluoroacetyl-protected amino acid chlorides in peptide coupling reactions with virtually complete preservation of stereochemistry

The use of protected amino acid chlorides for peptide coupling reactions has long been avoided due to the extensive racemization that commonly occurs during either the acid chloride formation or the coupling reaction itself. Conditions are described which

Effect of N-trifluoroacetyl derivatives of amino acids and amino acid analogs on microbial antitumor screen

Eighteen trifluoroacetyl derivatives of amino acids and of amino acid analogs were prepared and tested for growth-inhibitory activity. Of the compounds tested, the trifluoroacetyl derivatives of o-, m-, and p-fluorophenylalanine and β-3-thienylalanine showed modest activity; trifluoroacetyl derivatives of phenylalanine and of β-2-thienylalanine showed marginal activity. The activity exhibited by the active trifluoroacetyl compounds was equal to that noted for most active chloroacetyl derivatives reported previously, as judged by comparison of their activity with that of chloroacetyl-m-fluorophenylalanine. No reversal of inhibition was noted when a representative of these inhibitors was challenged with a corresponding natural metabolite, both as free amino acid and as a noninhibitory acylated compound.