350-10-7

Basic information

• Product Name: N-(trifluoroacetyl)tyrosine
• CAS NO: 350-10-7
• Molecular Formula: C₁₁H₁₀F₃NO₄
• Molecular Weight: 277.1966
• Mol File: 350-10-7.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 466.6°C at 760 mmHg
• Flash Point: 236°C
• Density: 1.478g/cm³
• Vapor Pressure: 1.66E-09mmHg at 25°C
• Refractive Index: 1.521
• CAS DataBase Reference: N-(trifluoroacetyl)tyrosine(CAS DataBase Reference)
• NIST Chemistry Reference: N-(trifluoroacetyl)tyrosine(350-10-7)
• EPA Substance Registry System: N-(trifluoroacetyl)tyrosine(350-10-7)

Safety Data

• Hazardous Substances Data: 350-10-7(Hazardous Substances Data)

Usage

General Description

N-(trifluoroacetyl)tyrosine is a chemical compound that is a derivative of the amino acid tyrosine. It is synthesized by replacing the hydrogen atom of the carboxyl group of tyrosine with a trifluoroacetyl group. This modification alters the chemical and physical properties of tyrosine, making it more hydrophobic and less polar. N-(trifluoroacetyl)tyrosine is commonly used as a standard in analytical chemistry and as a reagent in organic synthesis. It is also utilized in research and development of pharmaceuticals, agrochemicals, and other industrial applications. Additionally, its modified structure allows for easier detection and quantification in various analytical techniques such as liquid chromatography and mass spectrometry. Overall, N-(trifluoroacetyl)tyrosine is an important tool in the fields of chemistry and biotechnology.

Upstream product

• 3799-87-9 methyl (2,2,2-trifluoroacetyl)-L-tyrosinate 
• 60-18-4 L-tyrosine 
• 76-05-1 trifluoroacetic acid 
• 407-25-0 trifluoroacetic anhydride 
• 758-42-9 1,1,1-trichloro-3,3,3-trifluoro-propan-2-one 
• 383-63-1 ethyl trifluoroacetate, 
• 354-32-5 trifluoracetyl chloride 

Downstream Products

• 3870-24-4 N-(O-benzyl-N-trifluoroacetyl-DL-seryl)-L-tyrosine-(N'-trityl-hydrazide) 
• 3799-87-9 methyl (2,2,2-trifluoroacetyl)-L-tyrosinate 
• 467-27-6 N-trifluoroacetyl-L-tyrosine-(N'-trityl-hydrazide) 

Relevant articles and documents

TFA-protected α-amino acid N-hydroxysuccinimide ester: Application for inter- And intramolecular acylation

The utilization of N-trifluoroacetyl (TFA)-α-amino acid N-hydroxysuccinimide ester (OSu) derivatives, a promising acylating agent with high storage stability, is reported for Friedel-Crafts acylation into arenes and N-heterocycles. The reaction between TF

Effect of N-trifluoroacetyl derivatives of amino acids and amino acid analogs on microbial antitumor screen

Eighteen trifluoroacetyl derivatives of amino acids and of amino acid analogs were prepared and tested for growth-inhibitory activity. Of the compounds tested, the trifluoroacetyl derivatives of o-, m-, and p-fluorophenylalanine and β-3-thienylalanine showed modest activity; trifluoroacetyl derivatives of phenylalanine and of β-2-thienylalanine showed marginal activity. The activity exhibited by the active trifluoroacetyl compounds was equal to that noted for most active chloroacetyl derivatives reported previously, as judged by comparison of their activity with that of chloroacetyl-m-fluorophenylalanine. No reversal of inhibition was noted when a representative of these inhibitors was challenged with a corresponding natural metabolite, both as free amino acid and as a noninhibitory acylated compound.