35019-05-7

Upstream product

• 106-42-3 para-xylene 
• 22328-43-4 2,5-dimethylbenzoyl chloride 
• 553-94-6 4-bromo-m-xylene 
• 98-86-2 acetophenone 
• 201230-82-2 carbon monoxide 
• 79-37-8 oxalyl dichloride 
• 75-44-5 phosgene 

Downstream Products

• 109397-59-3 bis(2,5-dimethylphenyl)methanol 
• 29050-59-7 bis(2,5-dimethylphenyl)methane 
• 1356835-89-6 2-(bis(2,5-dimethylphenyl)methyl)-2,4,7-trimethyl-1H-indene-1,3(2H)-dione 
• 1356835-90-9 2-(bis(2,5-dimethylphenyl)methyl)-4,7-dimethyl-1H-indene-1,3(2H)-dione 
• 1356835-93-2 2-(bis(2,5-dimethylphenyl)methyl)-4,7-dimethyl-2,3-dihydro-1H-indene-1,3-diol 
• 1356835-98-7 2-(bis(2,5-dimethylphenyl)methyl)-1-chloro-4,7-dimethyl-1H-indene 

Relevant academic research and scientific papers

A palladium-catalyzed C-H functionalization route to ketones: Via the oxidative coupling of arenes with carbon monoxide

We describe the development of a new palladium-catalyzed method to generate ketones via the oxidative coupling of two arenes and CO. This transformation is catalyzed by simple palladium salts, and is postulated to proceed via the conversion of arenes into high energy aroyl triflate electrophiles. Exploiting the latter can also allow the synthesis of unsymmetrical ketones from two different arenes.

One-pot synthesis of diarylmethanones through palladium-catalyzed sequential coupling and aerobic oxidation of aryl bromides with acetophenone as a latent carbonyl donor

A one-pot palladium-catalyzed synthesis of symmetrical and unsymmetrical diarylmethanones using acetophenone and aryl bromides as raw materials has been developed. In this reaction, acetophenone acts as a latent carbonyl donor and two pathways of palladium-catalyzed sequential coupling and aerobic oxidation are identified. The reaction is applicable to a spectrum of substrates and delivers the products in moderate to good yields. This method can be used for the synthesis of ketoprofen, a nonsteroidal anti-inflammatory drug, in a two-step procedure and 45% overall yield.

Ortho-methylated tribenzotriquinacenes - Paving the way to curved carbon networks

The synthesis of sterically crowded tribenzotriquinacenes with complete and partial methylation of the ortho-positions has been achieved using the double cyclodehydration strategy. This leads to a twisted tribenzotriquinacene core and enables further func