35031-57-3

Usage

Chemical class

Ketone It is a type of organic compound with a carbonyl functional group (C=O) bonded to two alkyl or aryl groups.

Subclass

Butyrophenone A specific group of ketones that have a four-carbon chain and a phenyl ring attached to the carbonyl group.

Usage

Perfume production 2-4-dimethylbutyrophenone is used as a key ingredient in creating various fragrances due to its sweet, floral odor.

Usage

Flavoring agent It can be used to add flavor to food and beverages, enhancing their taste and aroma.

Usage

Synthesis of pharmaceuticals 2-4-dimethylbutyrophenone serves as an intermediate compound in the production of various pharmaceutical drugs.

Usage

Synthesis of other organic compounds It can be used as a building block in the creation of other organic compounds, contributing to the development of new materials and products.
8. Psychostimulant properties 2-4-dimethylbutyrophenone has been known to act as a psychostimulant, affecting the central nervous system and potentially offering therapeutic benefits.
9. Therapeutic potential The compound has been studied for its potential effects on the central nervous system, indicating possible applications in treating neurological disorders or conditions.

Upstream product

• 64-18-6 formic acid 
• 4214-28-2 1-iodo-2,4-dimethylbenzene 
• 106-94-5 propyl bromide 
• 17695-46-4 7-(propylcarbonyl)oxy-4-methyl-2H-1-benzopyran-2-one 
• 108-38-3 m-xylene 
• 106-31-0 butanoic acid anhydride 
• 141-75-3 butyryl chloride 

Downstream Products

• 861776-98-9 1-(2,4-dimethyl-5-nitro-phenyl)-butan-1-one 
• 776279-83-5 2-oxo-2-(2,4-dimethylphenyl)acetic acid 
• 854179-23-0 (+/-)-[2.4]xylyl-butanol-⁽¹⁾ 
• 1601-73-6 1-butyl-2,4-dimethyl-benzene 
• 854427-17-1 4-(2,4-dimethyl-phenyl)-butyric acid amide 
• 100387-96-0 2-bromo-1-(2,4-dimethyl-phenyl)-butan-1-one 

Relevant academic research and scientific papers

Palladium-Catalyzed Carbonylative Coupling of Aryl Iodides with Alkyl Bromides: Efficient Synthesis of Alkyl Aryl Ketones

Alkyl aryl ketones are important structures with applications in many areas of chemistry. Hence, efficient procedures for their production are particularly attractive. In this communication, a general and efficient carbonylative cross-coupling of aryl iodides and unactivated alkyl bromides is presented. By using a simple palladium catalyst, a series of alkyl aryl ketones were synthesized in moderate to excellent yields from readily available alkyl and aryl halides in an In-Ex tube with formic acid as the CO source. In this study both primary and secondary alkyl bromides/iodides were suitable coupling partners. Additionally, this method can also be employed for the late-stage functionalization of complex natural products and polyfunctionalized molecules. (Figure presented.).

Intermolecular character of the Fris rearrangement in the series of acyloxycoumarins

In the study of the Fris rearrangement in the series of 7-and 4-acyloxycoumarins we obtained certain data indicating intermolecular character of the rearrangement. The Fris rearrangement of a mixture of 7-benzoyloxy-4-metylcoumarin and 7-acetoxycoumarin results in formation of four reaction products in approximately equal molar ratio. Also, four products were obtained in the Fris rearrangement of 7-and 4-acyloxycoumarins in the presence of hydroxycoumarins. The Fris rearrangement of acyloxycoumarins in the presence of m-xylene at acylcoumarin-m-xylene ratio of 1:6 leads to the corresponding hydroxycoumarins and acylated m-xylenes. Intermediate formation of acylium ions was also detected by evolution of carbon monooxide at the Fris rearrangement of 7-pyvaloyloxy-and 7-isobutyryloxy-4-methylcoumarins. A product of intermolecular migration, 3-acetyl-4-hydoxy-6-methylcoumarin, was discovered also in the rearrangement of 4-acetoxycoumarin in the presence of 4-hydoxy-6-methylcoumarin catalyzed by phosphorus oxychloride.

Catalytic Friedel-Crafts Acylation Reactions Using Hafnium Triflate as a Catalyst in Lithium Perchlorate-Nitromethane

Catalytic Friedel-Crafts acylation reactions were performed by using hafnium trifluoromethanesulfonate (hafnium triflate, Hf(OTf)4) as a catalyst.The catalytic activity of the Lewis acid catalyst was much improved in lithium perchlorate-nitromethane (LiClO4-MeNO2) and the yield was up to 250,000percent based on the catalyst.Various substituted benzenes reacted with acid annhydrides in the presence of a catalytic amount of Hf(OTf)4 to give the corresponding aromatic ketones in high yields.