35060-38-9

Upstream product

• 644-13-3 C₆H₅COC₁₀H₇ 
• 613-62-7 2-benzyloxynaphthalene 
• 66-99-9 β-naphthaldehyde 
• 558-30-5 2-methyl-1,2-epoxypropane 
• 106-88-7 ethyloxirane 
• 96-09-3 styrene oxide 
• 124-38-9 carbon dioxide 
• 286-20-4 cyclohexane-1,2-epoxide 
• 108-94-1 cyclohexanone 
• 140-29-4 phenylacetonitrile 
• 4541-70-2 2-naphthyllithium 
• 100-52-7 benzaldehyde 
• 591-51-5 phenyllithium 
• 100-47-0 benzonitrile 

Downstream Products

• 858440-27-4 2-(α-bromo-benzyl)-naphthalene 
• 1148-92-1 2-(chloro(phenyl)methyl)naphthalene 
• 130778-69-7 α-(methoxy)-α-(phenyl)-2-methylnaphthalene 
• 128126-05-6 (3,5-Dinitro-phenyl)-carbamic acid (R)-naphthalen-2-yl-phenyl-methyl ester 
• 128126-05-6 (3,5-Dinitro-phenyl)-carbamic acid (S)-naphthalen-2-yl-phenyl-methyl ester 
• 147022-10-4 1-(Naphthalen-2-yl-phenyl-methyl)-1H-imidazole 
• 613-59-2 2-benzylnaphthalene 
• 644-13-3 C₆H₅COC₁₀H₇ 
• 123239-63-4 2-benzyl-[1]naphthoic acid 
• 1082852-38-7 2,2-dimethyl-5-phenylpent-4-ynoic acid naphthalen-2-yl-phenylmethyl ester 
• 1233537-00-2 2-(1-phenylbut-3-en-1-yl)naphthalene 
• 1234580-95-0 C₂₆H₁₈O₂ 
• 1260224-35-8 (R)-2-(1-phenylethyl)naphthalene 
• 1260224-34-7 (S)-2-(methoxy(phenyl)methyl)naphthalene 

Relevant academic research and scientific papers

Electrochemically driven catalytic Pd(0)/Cr(II) mediated coupling of organic halides with aldehydes. The Nozaki-Hiyama-Kishi reaction

An electrochemically driven, catalytic, Pd(0)/Cr(II) mediated coupling of organic halides with aldehydes is described. The reaction proceeds under mild conditions and the influence of reaction conditions and the mechanism are briefly discussed.

Bio-inspired asymmetric aldehyde arylations catalyzed by rhodium-cyclodextrin self-inclusion complexes

Transition-metal catalysts are powerful tools for carbon-carbon bond-forming reactions that are difficult to achieve using native enzymes. Enzymes that exhibit inherent selectivities and reactivities through host-guest interactions have inspired widesprea

Binaphthyl-prolinol chiral ligands: Design and their application in enantioselective arylation of aromatic aldehydes

Binaphthyl-prolinol ligands were designed and applied in enantioselective arylation of aromatic aldehydes and sequential arylation-lactonization of methyl 2-formylbenzoate. Under optimized conditions, the reactions provided the desired diarylmethanols and 3-aryl phthalides in up to 96% yields with up to 99% ee and up to 89% yields with up to 99% ee, respectively. In particular, essentially optically pure 3-aryl phthalides (over 99% ee) were obtained in large quantities through recrystallization. This journal is

Catalytic Aldehyde and Alcohol Arylation Reactions Facilitated by a 1,5-Diaza-3,7-diphosphacyclooctane Ligand

We report a catalytic method to access secondary alcohols by the coupling of aryl iodides. Either aldehydes or alcohols can be used as reaction partners, making the transformation reductive or redox-neutral, respectively. The reaction is mediated by a Ni catalyst and a 1,5-diaza-3,7-diphosphacyclooctane. This P2N2ligand, which has previously been unrecognized in cross-coupling and related reactions, was found to avoid deleterious aryl halide reduction pathways that dominate with more traditional phosphines and NHCs. An interrupted carbonyl-Heck type mechanism is proposed to be operative, with a key 1,2-insertion step forging the new C-C bond and forming a nickel alkoxide that may be turned over by an alcohol reductant. The same catalyst was also found to enable synthesis of ketone products from either aldehydes or alcohols, demonstrating control over the oxidation state of both the starting materials and products.

Bulky N-Heterocyclic-Carbene-Coordinated Palladium Catalysts for 1,2-Addition of Arylboron Compounds to Carbonyl Compounds

The synthesis of primary, secondary, and tertiary alcohols by the 1,2-addition of arylboronic acids or boronates to carbonyl compounds, including unactivated ketones, using novel bulky yet flexible N-heterocyclic carbene (NHC)-coordinated 2,6-di(pentan-3-yl)aniline (IPent)-based cyclometallated palladium complexes (CYPs) as catalysts is reported. The PhS-IPent-CYP-catalyzed reactions are efficient at low catalyst loadings (0.02–0.3 mol% Pd), and the exceptional catalytic activity for 1,2-addition is attributed to the steric bulk of the NHC ligand. These reactions can yield a wide range of functionalized benzylic alcohols that are difficult to synthesize by classical protocols using highly active organomagnesium or lithium reagents.

Transition-Metal-Free Reductive Functionalization of Tertiary Carboxamides and Lactams for α-Branched Amine Synthesis

A new method for the synthesis of α-branched amines by reductive functionalization of tertiary carboxamides and lactams is described. The process relies on the efficient and controlled reduction of tertiary amides by a sodium hydride/sodium iodide composite, in situ treatment of the resulting anionic hemiaminal with trimethylsilyl chloride and subsequent coupling with nucleophilic reagents including Grignard reagents and tetrabutylammonium cyanide. The new method exhibits broad functional-group compatibility, operates under transition-metal-free reaction conditions, and is suitable for various synthetic applications on both sub-millimole and on multigram scales.

Asymmetric Deoxygenative Cyanation of Benzyl Alcohols Enabled by Synergistic Photoredox and Copper Catalysis?

Summary of main observation and conclusion. An enantioselective deoxygenative cyanation of benzyl alcohols was accomplished for the first time through the synergistic photoredox and copper catalysis. This reaction features the use of organic photosensitizer and low-cost 3d metal catalyst, simple and safe operations, and extremely mild conditions. A variety of chiral benzyl nitriles were produced in generally good yields and high level of enantiocontrols from readily available feedstocks (22 examples, up to 93% yield and 92% ee).

Asymmetric Hydrophosphination of Heterobicyclic Alkenes: Facile Access to Phosphine Ligands for Asymmetric Catalysis

Asymmetric hydrophosphination is the most atomically economical and straightforward approach to the construction of chiral organophosphorus compounds. Good stereoselectivities have been achieved in asymmetric hydrophosphination of an electron-deficient C=

Nickel Catalyzed Intermolecular Carbonyl Addition of Aryl Halide

In this study, we develop a nickel-catalyzed carbonyl arylation reaction employing aldehydes with aryl and allyl halides. Various aryl, α,β-unsaturated aldehyde and aliphatic aldehydes can be converted into their corresponding secondary alcohols in moderate-to-high yields. In addition, we extended this approach to develop an asymmetric reductive coupling reaction that combines nickel salts with chiral bisoxazoline ligands to give secondary alcohols with moderate enantioselectivity.

Combined Photoredox/Enzymatic C?H Benzylic Hydroxylations

Chemical transformations that install heteroatoms into C?H bonds are of significant interest because they streamline the construction of value-added small molecules. Direct C?H oxyfunctionalization, or the one step conversion of a C?H bond to a C?O bond, could be a highly enabling transformation due to the prevalence of the resulting enantioenriched alcohols in pharmaceuticals and natural products,. Here we report a single-flask photoredox/enzymatic process for direct C?H hydroxylation that proceeds with broad reactivity, chemoselectivity and enantioselectivity. This unified strategy advances general photoredox and enzymatic catalysis synergy and enables chemoenzymatic processes for powerful and selective oxidative transformations.