351195-17-0

Upstream product

• 100-52-7 benzaldehyde 
• 536975-49-2 phenyl (trimethylsilyl)difluoromethyl sulfide 
• 1535-67-7 difluoromethyl phenyl sulfide 
• 614-47-1 1,3-diphenyl-propen-3-one 
• 108-98-5 thiophenol 
• 384-67-8 2-chloro-2,2-difluoroacetophenone 
• 78031-08-0 [(bromodifluoromethyl)sulfanyl]benzene 
• 930-69-8 sodium thiophenolate 
• 899820-34-9 2,2-difluoro-1-phenyl-2-phenylsulfanyl-1-trimethoxysiloxyethane 
• 132088-32-5 2,2-difluoro-1-phenyl-2-(phenylsulfanyl)ethanone 

Downstream Products

• 82255-42-3 2,2-difluoro-1-phenyl-ethanol 
• 122590-86-7 2,2-difluoro-1-phenyl-2-(phenylsulfonyl)ethan-1-ol 

Relevant academic research and scientific papers

Nucleophilic gem-difluoro(phenylsulfanyl)methylation of carbonyl compounds with PhSCF2H in the presence of a phosphazene as a base

Direct nucleophilic gem-difluoro(phenylsulfanyl)methylation of carbonyl compounds has been achieved by use of difluoro(phenylsulfanyl)methane (PhSCF2H) and the phosphazene base P4-tBu in THF. Non-enolizable aldehydes and ketones are suitable substrates to undergo nucleophilic gem-difluoro(phenylsulfanyl)methylation, providing α-gem-difluoromethylated adducts in good yields. In addition, this methodology is also applicable with cyclic imides and acid anhydrides. Direct nucleophilic gem-difluoro(phenylsulfanyl)methylation of aromatic aldehydes and ketones, cyclic imides, and acid anhydrides with difluoro(phenylsulfanyl)methane (PhSCF2H) reagent was achieved in the presence of the phosphazene P4-tBu as a base. The corresponding adducts should be useful for further synthetic conversion into a variety of fluorinated compounds. Copyright

Difluoro(phenylchalcogen)methylation of aldehydes, ketones, and imines with S-, Se-, and Te-containing reagents PhXCF2H (X = S, Se, Te)

A series of sulfur-, selenium- and tellurium-containing (phenylchalcogen)difluoromethylation reagents PhSCF2H (1a), PhSeCF2H (1b), and PhTeCF2H (1c) were prepared, and their relative reactivity towards aldehydes, ketones,

α,α-Difluoro-α-phenylsulfanylmethyl carbanion equivalent: a novel gem-difluoromethylenation of carbonyl compounds

α,α-Difluoro-α-phenylsulfanyl-α-trimethylsilylmethane (PhSCF2SiMe3) has been demonstrated as an α,α-difluoro-α-phenylsulfanylmethyl carbanion equivalent. gem-Difluorophenylsulfanylmethylation of carbonyl compounds has been successful

Fluoride-induced nucleophilic (phenylthio)difluoromethylation of carbonyl compounds with [difluoro(phenylthio)methyl]trimethylsilane (TMS-CF 2SPh)

A fluoride-induced nucleophilic (phenylthio)difluoromethylation method using TMS-CF2SPh has been achieved. This new methodology efficiently transfers "PhSCF2" group into both enolizable and non-enolizable aldehydes and ketones to giv

Synthesis of α-(heteroarylthio)-α,α-difluoroacetophenone derivatives via the SRN1 methodology

New α-(heteroarylthio)-α,α-difluoroacetophenone Ar1-COCF2S-Ar2 derivatives 8-15 were synthesized in moderate to good yields via the SRN1 methodology, from the reaction of a series of chlorodifluoromethylated ketones 1-4 with aromatic and heterocyclic thiols 5-7. The corresponding Ar1-CHOHCF2S-Ar2 16-23 were also prepared in moderate yields, using sodium borohydride in absolute ethanol. The compounds may find some biological applications as potent anti-HIV-1 as well as useful synthons for agrochemicals.