351380-18-2Relevant academic research and scientific papers
The solution to a deep stereochemical conundrum: Studies toward the tetrahydroisoquinoline alkaloids
Chan, Collin,Zheng, Shengping,Zhou, Bishan,Guo, Jinsong,Heid, Richard M.,Wright, Benjamin J. D.,Danishefsky, Samuel J.
, p. 1749 - 1754 (2007/10/03)
(Chemical Equation Presented) Facile construction of subunits 1 and 2 allowed the rapid assembly of the pentacyclic ring system 3 of the cytotoxic tetrahydroisoquinoline alkaloids. A surprising participation reaction was discovered, which necessitated rev
Total synthesis of cribrostatin IV: Fine-tuning the character of an amide bond by remote control
Chan, Collin,Heid, Richard,Zheng, Shengping,Guo, Jinsong,Zhou, Bishan,Furuuchi, Takeshi,Danishefsky, Samuel J.
, p. 4596 - 4598 (2007/10/03)
We report the enantioselective total synthesis of cribrostatin IV (1). Key features of this synthesis involve the convergent coupling of two highly functionalized homochiral components followed by a "lynchpin" Mannich cyclization to establish the pentacyc
