3516-73-2

Upstream product

• 118-91-2 ortho-chlorobenzoic acid 
• 609-65-4 o-chlorobenzoyl chloride 
• 105-53-3 diethyl malonate 

Downstream Products

• 19112-35-7 ethyl (2-chlorobenzoyl)acetate 
• 289706-53-2 ethyl (2'-chlorophenyl)-3-oxo-2-(N-ethylamino)methylene propionate 
• 60868-43-1 2-(2-chlorobenzoyl)-3-ethoxyacrylic acid ethyl ester 

Relevant academic research and scientific papers

Zinc-mediated alkylation and acylation of 1,3-dicarbonyl compounds

1,3-Dicarbonyl compounds undergo smooth allylation, benzylation, propargylation, and acylation with halides using metallic zinc in DMF at 60 °C to afford the corresponding allyl, benzyl, 2-propynyl, and acylated 1,3-diesters in good yields. In the case of cyclic 1,3-diketones, the corresponding enol ethers are obtained as sole products instead of C-alkylation.

Cycloaracylation of Enamines, I. - Synthesis of 4-Quinolone-3-carboxylic Acids

Starting with o-halobenzoyl chlorides 4 and open-chain secondary enamines 5, a new synthesis of 4-quinolone-3-carboxylic acids 12 is described.The reaction of 7-haloquinolone-3-carboxylic acids 12a-k with aliphatic amines 14 produces highly active antibacterial 7-aminoquinolone-3-carboxylic acids 15.The main product of the 1-cyclopropyl series, "ciprofloxacin" (15a), is being developed as a broad-spectrum chemotherapeutic agent.