35188-64-8

Upstream product

• 100-39-0 benzyl bromide 
• 1073-69-4 N-4-chlorophenylhydrazine 
• 2725-46-4 1-benzyl-2-benzylidene-1-phenylhydrazine 
• 588-64-7 benzaldehyde phenylhydrazone 
• 106-47-8 4-chloro-aniline 
• 2833-68-3 benzaldehyde-p-chlorophenylhydrazone 
• 1073-70-7 4-chlorophenylhydrazine hydrochloride 
• 100-52-7 benzaldehyde 

Downstream Products

• 39235-96-6 1-benzyl-5-chloro-2-phenyl-1H-benzo[d]imidazole 

Relevant academic research and scientific papers

A one-pot synthesis of bisarylhydrazones by Cu(I)-catalyzed aerobic oxidation

An efficient Cu(I)-catalyzed one-pot synthesis of N-substituted (or NH) bisarylhydrazones is reported. A further cyclization reaction could occur towards the synthesis of benzimidazoles or triazoles with elevated temperature. A plausible alkylation-oxidation-alkylation mechanism is proposed based on experimental results and literature.

Copper-mediated synthesis of substituted 2-aryl-N-benzylbenzimidazoles and 2-arylbenzoxazoles via C-H functionalization/C-N/C-O bond formation

An efficient method for the transformation of N-benzyl bisarylhydrazones and bisaryloxime ethers to functionalized 2-aryl-N-benzylbenzimidazoles and 2-arylbenzoxazoles is described. The protocol involves a copper(II)-mediated cascade C-H functionalization/C-N/C-O bond formation under neutral conditions. Substrates having either electron-donating or -withdrawing substituents undergo the cyclization to afford the target heterocycles at moderate temperature.