35191-43-6Relevant academic research and scientific papers
Substrate and Catalyst Effects in the Enantioselective Copper-Catalysed C–H Insertion Reactions of α-Diazo-β-oxo Sulfones
Shiely, Amy E.,Clarke, Leslie-Ann,Flynn, Christopher J.,Buckley, Aoife M.,Ford, Alan,Lawrence, Simon E.,Maguire, Anita R.
supporting information, p. 2277 - 2289 (2018/06/04)
Excellent enantioselectivities of up to 98 % ee are achieved by employing the copper-bis(oxazoline)-NaBARF catalyst system in the C–H insertion reactions of α-diazo-β-oxo sulfones. The influence of variation of the bis(oxazoline) ligand, copper salt, additive and substrate on both the efficiency and the enantioselectivities of these intramolecular C–H insertion reactions has been explored. Optimum enantioselectivities are achieved with phenyl and diphenyl ligands across the substrate series.
Azole derivatives
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Page/Page column 13, (2010/10/20)
Compounds of formula I their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and racemates, are disclosed. Also disclosed are methods of preparation of the above-mentioned compounds, pharmaceutical compositions and salts and esters
Novel pentafluorosulfanyl compounds
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Page/Page column 13, (2010/02/13)
The present invention provides the compounds of formula I-A their pharmaceutically acceptable salts or esters, enantiomeric forms, diastereoisomers and racemates, the preparation of the above-mentioned compounds, pharmaceutical compositions containing th
Novel oxidized thioether derivatives
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Page/Page column 11, (2010/02/13)
The present invention provides the compounds of formula I their pharmaceutically acceptable salts or esters, enantiomeric forms, diastereoisomers and racemates, the preparation of the above-mentioned compounds, pharmaceutical compositions containing them
A facile synthesis of di-O-methyl centrolobol
Panda, Atulya Kumar
, p. 372 - 375 (2007/10/03)
A facile route to (±)di-O-methyl centrolobol 4 has been explored starting from 4-oxo-4-(4-methoxyphenyl) butanoic acid 7 and 4-methoxycinnamic acid 13.
Structure-activity relationship for a series of 2-substituted 1,2,3,4- tetrahydro-9H-pyrido[3,4-b]indoles: Potent subtype-selective inhibitors of N- methyl-D-aspartate (NMDA) receptors
Tamiz, Amir P.,Whittemore, Edward R.,Woodward, Richard M.,Upasani, Ravindra B.,Keana, John F.W.
, p. 1619 - 1624 (2007/10/03)
A series of 2-substituted 1,2,3,4-tetrahydro-9H-pyrido[3,4-b]indoles was synthesized as potential antagonists for the NR1(A)/2B subtype of N-methyl- D-aspartate (NMDA) receptors. Assayed by electrical recording under steady- state conditions, 7-hydroxy-2-(4-phenylbutyl)-1,2,3,4-tetrahydropyrido-[3,4- b]indole (30) was the most potent compound in the series having an IC50 value of 50 nM at the NR1(A)/2B receptors.
An approach to the biomimetic synthesis of aryltetralin lignans
Pelter, Andrew,Ward, Robert S.,Rao, Ramohan R.
, p. 2933 - 2938 (2007/10/02)
The BF3 catalysed cyclisation of 3-arylpropyl substituted quinone-methide ketals affords a mild, biomimetic route to aryltetralins. 1H- and 13C-NMR spectra of the products are reported.
Synthesis of meta,meta-Bridged Biaryls (-Metacyclophanes) via Aryl-Aryl Coupling: Factors affecting the Cyclisation
Mohamed, Salah E.N.,Whiting, Donald A.
, p. 2577 - 2582 (2007/10/02)
Two bis(iodoaryl)heptanoids (28) and (33), the iodoarylbutyl iodoarylpropyl sulphide (39), and the corresponding sulphone (40) have been prepared, and each treated with tetrakis(triphenylphosphine)nikel(0).Two new m,m-bridged biaryls (29) (31percent) and (34) (49percent) were obtained; the sulphur compounds were deiodinated in preference to coupling.These reactions are compared with those used previously in myricanol synthesis and the factors affecting ring closure are discussed.Steric effects at the coupling sites appear more important in determining product yield than torsional strain in the products.
PREPARATION OF HOMOLOGS OF L-2-AMINO-5-(p-METOXYPHENYL)PENTANOIC ACID
Kosui, Nobuo,Waki, Michinori,Kato, Tetsuo,Izumiya, Nobuo
, p. 918 - 920 (2007/10/02)
Lower and higher homologs, L-2-amino-4-(p-methoxyphenyl)butanoic acid (L-amb) and L-2-amino-6-(p-methoxyphenyl)hexanoic acid (L-Amh), of L-2-amino-5-(p-methoxyphenyl)pentanoic acid were prepared by optical resolution of N-acetyl-DL-Amb and of N-acetyl-DL-Amh with Aspergillus acylase.N-acetyl DL-Amb or N-acetyl-DL-Amh was synthesized from (acetamido malonic acid by heating with p-xylene.
