352018-92-9

Usage

Uses

Used in Pharmaceutical Industry:
5-IODO-2-PHENOXYPYRIDINE is used as a building block for the synthesis of various pharmaceutical products due to its unique chemical structure and properties.
Used in Research and Development:
5-IODO-2-PHENOXYPYRIDINE is utilized in research and development for the creation of new chemical compounds for medicinal purposes, contributing to the discovery of novel therapeutic agents.
Used in Agrochemical Industry:
5-IODO-2-PHENOXYPYRIDINE is used as a potential active ingredient in the production of agrochemicals for crop protection and pest control, leveraging its chemical properties to enhance agricultural productivity and sustainability.

InChI:InChI=1/C11H8INO/c12-9-6-7-11(13-8-9)14-10-4-2-1-3-5-10/h1-8H

Upstream product

• 73290-22-9 2-bromo-5-iodo-pyridine 
• 108-95-2 phenol 
• 25194-67-6 6-phenoxy-pyridin-3-ylamine 
• 4487-59-6 2-bromo-5-nitropyridine 
• 28222-02-8 3-nitro-6-phenoxypyridine 

Downstream Products

• 1024592-19-5 C₂₀H₁₅NO₂ 
• 1024592-20-8 C₂₁H₁₇NO₃ 
• 1258870-91-5 2-phenoxy-5-phenylsulfanylpyridine 
• 1353767-43-7 (S)-N-{1-[4-(6'-phenoxy-3,4,5,6-tetrahydro-2H-[1,3']bipyridinyl-4-yl)phenyl]ethyl}acetamide 

Relevant academic research and scientific papers

Aminoarenethiolato-copper(I) as (pre-)catalyst for the synthesis of diaryl ethers from aryl bromides and sequential C-O/C-S and C-N/C-S cross coupling reactions

A small library of 2-aminoarenethiolato-copper(I) (CuSAr) complexes was tested as (pre-)catalysts in the arylation reaction of phenols with aryl bromides. These copper(I) (pre-)catalysts are thermally stable, soluble in common organic solvents, and allow reactions of 6 h at 160 °C with low catalyst loadings of 2.5 mol %. Among the (pre-)catalysts screened, 2-[(dimethylamino)methyl]benzenethiolato-copper(I) (1c) led to the best results and provided good to excellent yields of various substituted diaryl ethers. Mechanistic studies showed that at early stages of the C-O coupling reaction the CuSAr complex is converted into CuBr(PhSAr) via selective coupling of the monoanionic arenethiolato ligand with phenyl bromide with formation of CuBr. In addition, the first results are shown involving a multi-component reaction (MCR) protocol for the in situ synthesis of propargylamines and their subsequent conversion involving a C-O cross coupling reaction. Furthermore, two examples of sequential C-O/C-S and C-N/C-S cross coupling reactions have been carried out on the same dihalo-pyridine substrate in a one-pot process with the same (CuSAr) (pre-)catalyst (overall yields 40-80%).

Cycloauration of substituted 2-phenoxypyridine derivatives and X-ray crystal structure of gold, dichloro[2-[[5-[(cyclopentylamino) carbonyl]-2-pyridinyl-κN]oxy]phenyl-κC]-, (SP-4-3)-

Direct cycloauration of 2-phenoxypyridines with different substituents at the 5-position of the pyridine ring was carried out in an CH3CN/H2O medium, leading to isolation of cycloaurated compounds AuCl2(L) (HL = substitute