352297-87-1

Upstream product

• 100-52-7 benzaldehyde 
• 618902-03-7 3-(2-amino-1-methyl-ethyl)-1-(2,6-difluoro-benzyl)-5-(3-methoxy-phenyl)-6-methyl-1H-pyrimidine-2,4-dione 
• 618902-01-5 3-[2-N-Boc-amino-1-(S)-methylethyl]-5-bromo-1-(2,6-difluorobenzyl)-6-methyluracil 
• 618914-13-9 1-(2,6-difluorobenzyl)-3-(3-oxobutyryl)urea 
• 352303-66-3 5-bromo-1-(2,6-difluoro-benzyl)-6-methyl-1H-pyrimidine-2,4-dione 
• 352303-65-2 N-1-(2,6-difluorobenzyl)-6-methyluracil 
• 17751-24-5 N-(2,6-difluorobenzyl) urea 
• 69385-30-4 2,6-difluorobenzylamine 

Relevant academic research and scientific papers

Synthesis and Structure-Activity Relationships of 1-Arylmethyl-5-aryl-6-methyluracils as Potent Gonadotropin-Releasing Hormone Receptor Antagonists

Based on the SAR from bicyclic gonadotropin-releasing hormone (GnRH) antagonists such as 6-aminomethyl-7-aryl-pyrrolo [1,2-a] pyrimid-4-ones (5) and 2-aryl-3-aminomethyl-imidazolo-[1,2-a]pyrimid-5-ones (6a,b), a series of novel uracil compounds (8) were d

Synthesis and structure-activity relationships of 1-arylmethyl-3-(1-methyl-2-amino)ethyl-5-aryl-6-methyluracils as antagonists of the human GnRH receptor

A new class of small molecule GnRH antagonists, the 1-arylmethyl-3-(1-methyl-2-amino)ethyl-5-aryl-6-methyluracils, was designed and a novel stereoselective synthesis for these compounds was developed. The stereochemical integrities of key intermediates (S