352547-72-9

Upstream product

• 922-68-9 Methyl glyoxylate 
• 98-86-2 acetophenone 
• 39757-29-4 methyl 2,4-dioxo-4-p-tolylbutanoate 
• 65245-10-5 2-hydroxy-4-oxo-4-phenylbutanoic acid 
• 74-88-4 methyl iodide 

Downstream Products

• 14274-07-8 methyl trans-β-benzoylacrylate 
• 244090-26-4 2-phenyl-5,6,7,8-tetrahydroquinoline-4-carboxylic acid 
• 244090-25-3 methyl 2-phenyl-5,6,7,8-tetrahydroquinoline-4-carboxylate 

Relevant academic research and scientific papers

InCl3-Catalyzed direct aldol reactions of glyoxylic acid monohydrate and glyoxylates with various ketones: Scope and limitations

The direct aldol reactions of various ketones with glyoxylic acid and glyoxylates afforded the α-hydroxy acid and α-hydroxy esters in good yields and high regioselectivities.

Polarographic behavior of methyl 4-aryl-2,4-dioxobutanoates

Polarographic reduction of methyl 4-aryl-2,4-dioxobutanoates in aqueous 2-propanol involves two cathodic waves and yields methyl 4-aryl-2,4-dihydroxybutanoates.

Replacement of the quinoline system in 2-phenyl-4-quinolinecarboxamide NK-3 receptor antagonists

Results from a medicinal chemistry approach aimed at replacing the quinoline ring system in the potent and selective human neurokinin-3 (hNK-3) receptor antagonists 1-4 of general formula I are discussed. The data give further insight upon the potential NK-3 pharmacophore. In particular, it is highlighted that both the benzene-condensed ring and the quinoline nitrogen are crucial determinants for optimal binding affinity to the hNK-3 receptor. Some novel compounds maintained part of the binding affinity to the receptor (5, 6, 10 and 13) and compound 5, featuring the naphthalene ring system, appears to be suitable for further modifications: it offers the option to introduce electron-withdrawing groups at position 2 and 4, conferring on the ring an overall electron-deficiency similar to that of the quinoline.