35267-14-2Relevant academic research and scientific papers
PHARMACEUTICAL COMPOUNDS AND THEIR USE AS INHIBITORS OF UBIQUITIN SPECIFIC PROTEASE 19 (USP19)
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Page/Page column 275, (2020/07/04)
Provided are USP19 inhibitors, methods of treating obesity, metabolic syndrome and/or diabetes using the USP19 inhibitor compounds, as well as those compounds for use in methods of treating obesity, metabolic syndrome and/or diabetes. Also provided are methods of treating muscular atrophy, for example cachexia or sarcopenia with USP19 inhibitor compounds, plus those compounds for use in methods of treating muscular atrophy.
4-HYDROXYPIPERIDINE DERIVATIVES AND THEIR USE AS INHIBITORS OF UBIQUITIN SPECIFIC PROTEASE 19 (USP19)
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Page/Page column 256, (2019/08/26)
Inhibitors of ubiquitin specific protease 19 (USP19) of Formula (I) are provided, together with pharmaceutical compositions comprising said inhibitors, and methods of use thereof. The compounds can be used in in the treatment of muscular atrophy, obesity, insulin resistance or type II diabetes or in reducing the loss of muscle mass.
A fluorescent probe for hypochlorite based on the modulation of the unique rotation of the N-N single bond in acetohydrazide
Long, Lingliang,Wu, Yanjun,Wang, Lin,Gong, Aihua,Hu, Feilong,Zhang, Chi
supporting information, p. 10435 - 10438 (2015/06/25)
Herein, a novel signaling mechanism for constructing fluorescent probes was demonstrated for the first time based on modulation of the unique rotation of the N-N single bond in the acetohydrazide group. According to the new signaling mechanism, a fluorescent probe for hypochlorite was then judiciously developed.
Synthesis of 1-phenyl-2-(phenylcarbamoyl)pyrazolidines as potential anticonvulsant agents
Kornet,Garrett
, p. 377 - 378 (2007/10/04)
Twelve 1-phenyl-2-(phenylcarbamoyl)pyrazolidines were synthesized from 1-arylpyrazolidines and aryl isocyanates. These adducts showed little anticonvulsant activity in the maximal electroshock seizure and pentylenetetrazol seizure assays.
