936-53-8

Usage

Synthesis Reference(s)

Synthesis, p. 1028, 1985 DOI: 10.1055/s-1985-31422

Upstream product

• 1126-00-7 1-phenylpyrazole 
• 100-63-0 phenylhydrazine 
• 109-64-8 1,3-dibromo-propane 
• 107-02-8 acrolein 
• 142-28-9 1,3-Dichloropropane 
• 59-88-1 phenylhydrazine hydrochloride 
• 62-53-3 aniline 
• 5469-66-9 propane-1,3-diol ditosylate 
• 96-21-9 1,3-dibromo-2-hydroxypropane 
• 35267-14-2 N-phenylpyrazolidine 

Downstream Products

• 2538-52-5 1,3-diphenyl-4,5-dihydro-1H-pyrazole 
• 49663-40-3 3-(4-bromo-phenyl)-1-phenyl-4,5-dihydro-1H-pyrazole 
• 20264-80-6 3-(4-chloro-phenyl)-1-phenyl-4,5-dihydro-1H-pyrazole 
• 1126-00-7 1-phenylpyrazole 
• 23429-68-7 1,1'-diphenyl-4,5,4',5'-tetrahydro-1H,1'H-[3,3']bipyrazolyl 
• 4742-01-2 N-(3-aminopropyl)aniline 
• 4747-46-0 1-phenyl-1H-pyrazole-3-carboxylic acid 
• 77393-38-5 1,1'-diphenyl-1H,1'H-[3,3']bipyrazolyl 
• 105257-97-4 3-phenyl-1-(4-phenylazo-phenyl)-4,5-dihydro-1H-pyrazole 
• 90915-04-1 1-phenyl-4,5-dihydro-1H-pyrazole-3-carbaldehyde 
• 1448427-11-9 1-(4-(4,5-dihydro-1H-pyrazol-1-yl)phenylsulfonyl)-4-methyl-1,2,3,4-tetrahydroquinoxaline 
• 78369-87-6 1-phenyl-3-m-tolyl-4,5-dihydro-1H-pyrazole 

Relevant academic research and scientific papers

Fe(III)-Catalyzed Aerobic Intramolecular N-N Coupling of Aliphatic Azides with Amines

An Fe(III)-catalyzed intramolecular N-N coupling of aliphatic azidoamines that forms diverse five- and six-membered semisaturated diazoheterocycles using air as an oxidant is reported, providing an alternative to hydrazine-based methods. Mechanistic studies suggest that a N-radical induced intramolecular homolytic substitution (SH2) is involved in ring closure. The power of this N-N bond-forming method is also demonstrated by using it as the final step in a total synthesis of (-)-newbouldine.

Novel tertiary sulfonamides as potent anti-cancer agents

For adult women in the United States, breast cancer is the most prevalent form of cancer. Compounds that target dysregulated signal transduction can be efficacious anti-cancer therapies. A prominent signaling pathway frequently dysregulated in breast canc

Synthesis, optical and nonlinear optical properties of new pyrazoline derivatives

We report on synthesis and optical properties of new organic compounds based on substituted pyrazole ring. The investigated pyrazoline derivatives (PRDs) exhibit efficient broadband photoluminescence which covers nearly whole visible spectrum. The experimental results are compared to quantum chemical calculations. Amplified spontaneous emission and photodegradation measurements were performed for hybrid systems based on selected PRDs doped into poly(methyl methacrylate) matrix proving the potential utility of such systems in lasing applications. Two-photon absorption (TPA) properties were characterized by the femtosecond Z-scan technique.

Aqueous N-heterocyclization of primary amines and hydrazines with dihalides: Microwave-assisted syntheses of N-azacycloalkanes, isoindole, pyrazole, pyrazolidine, and phthalazine derivatives

The synthesis of nitrogen-containing heterocycles from alkyl dihalides (ditosylates) and primary amines and hydrazines via a simple and efficient cyclocondensation in an alkaline aqueous medium that occurs under microwave irradiation is described. This improved greener synthetic methodology provides a simple and straightforward one-pot approach to the synthesis of a variety of heterocycles, such as substituted azetidines, pyrrolidines, piperidines, azepanes, N-substituted 2,3-dihydro-1H-isoindoles, 4,5-dihydropyrazoles, pyrazolidines, and 1,2-dihydrophthalazines.

Microwave-assisted cyclocondensation of hydrazine derivatives with alkyl dihalides or ditosylates in aqueous media: Syntheses of pyrazole, pyrazolidine and phthalazine derivatives

Direct syntheses of 4,5-dihydro-pyrazole, pyrazolidine, and 1,2-dihydro-phthalazine derivatives via double-alkylation of hydrazines by alkyl dihalides or ditosylates were accomplished in aqueous media under microwave irradiation conditions; the environmen