5472-00-4

Upstream product

• 93501-23-6 2-Bromo-3,3-diphenyl-propionic acid phenyl ester 
• 40326-95-2 phenyl α,β-dibromohydrocinnamate 
• 71-43-2 benzene 
• 606-84-8 3,3-diphenylacrylic acid 
• 108-95-2 phenol 
• 119-61-9 benzophenone 
• 3531-23-5 3-hydroxy-3,3-diphenylpropanenitrile 
• 3531-24-6 3,3-diphenylacrylonitrile 

Downstream Products

• 55010-17-8 3,3-diphenyl-indan-1-one 
• 971-84-6 4,4-diphenyl-3,4-dihydrocoumarin 
• 35491-05-5 (E) 2-(2,2-diphenylethenyl)-1,3-benzoxazole 
• 41916-15-8 3-phenyl-1H-inden-1-one 

Relevant academic research and scientific papers

Method of coupling, and the coupling method using the aromatic group-substituted heterocyclic compound

Provided is an easy method (coupling method) capable of easily synthesizing a compound group in which aromatic molecules and aromatic molecules are coupled, a compound group in which aromatic molecules and alkene molecules are coupled, and the like without producing halogen waste and without the need to use scarce and expensive palladium. A compound (A) shown by general formula (A): Ar-H and a compound (B1) shown by general formula (B1): RaOCO-Ar', a compound (B2) shown by general formula (B2): RbCH=C(Ar")2, or a compound (B3) shown by general formula (B3): RcOCOCH=C(Ar")2 are reacted in the presence of a nickel compound.

C-H alkenylation of azoles with enols and esters by nickel catalysis

Rather u(Ni)que: Two new C-H alkenylation reactions, that is C-H/Ci￡O alkenylation and decarbonylative C-H alkenylation, of azoles are uniquely catalyzed by Ni/dcype. These azole alkenylation reactions are successfully applied to the convergent formal synthesis of siphonazoleB.

A New Route for the Synthesis of Coumarins, Thiacoumarins and Carbostyrils

3-Arylcarbostyrils, coumarins and thiacoumarins (3) have been prepared from the respective β-aryl-α-bromodihydrocinnamoyl derivatives (2) by treatment with AlCl3.The β,β-diarylacrylic acid derivatives (4) and (9), obtained from 2, on reaction with AlCl3 afford 4-arylcarbostyrils (5) 6-methyl-4-phenylthiacoumarin (10) respectively.However the oxygen analogs (11) give 3,3-diphenyl-1-indanone (12)