353242-45-2

Upstream product

• 98-59-9 p-toluenesulfonyl chloride 
• 1025803-35-3 (S)-3-acetamido-7-methoxy-1,2,3,4-tetrahydro-quiniline 
• 353242-43-0 (S)-N-(1-methanesulfonyloxymethyl-2-(4-methoxy-2-nitrophenyl)-ethyl)-acetamide 
• 353242-37-2 (Z)-2-N-acetylamino-3-(4-methoxy-2-nitrophenyl)acrylic acid methyl ester 
• 22996-21-0 4-methoxy-2-nitro-benzaldehyde 
• 58755-70-7 1-iodo-4-methoxy-2-nitrobenzene 
• 38469-83-9 4-methoxy-2-nitro-benzonitrile 
• 35356-70-8 Methyl 2-acetamidoacrylate 
• 353242-39-4 (S)-2-N-acetylamino-3-(4-methoxy-2-nitrophenyl)propionic acid methyl ester 
• 353242-42-9 (S)-N-(1-hydroxymethyl-2-(4-methoxy-2-nitrophenyl)-ethyl)-acetamide 
• 96-96-8 4-methoxy-2-nitroaniline 

Relevant academic research and scientific papers

Asymmetric Synthesis of Functionalized 1,2,3,4-Tetrahydroquinolines

Highly enantioselective rhodium-catalyzed asymmetric hydrogenation (>98% ee) and Sharpless epoxidation (>90% ee) of o-nitrocinnamyl substrates lead to intermediates that can be transformed into tetrahydroquinoline derivatives. Starting materials are produced in high-yielding Heck reactions of an o-nitroaryl iodide and α-acetamidoacrylate or methyl acrylate.