353242-42-9Relevant articles and documents
Asymmetric Synthesis of Functionalized 1,2,3,4-Tetrahydroquinolines
Gallou-Dagommer, Isabelle,Gastaud, Philippe,RajanBabu
, p. 2053 - 2056 (2007/10/03)
Highly enantioselective rhodium-catalyzed asymmetric hydrogenation (>98% ee) and Sharpless epoxidation (>90% ee) of o-nitrocinnamyl substrates lead to intermediates that can be transformed into tetrahydroquinoline derivatives. Starting materials are produced in high-yielding Heck reactions of an o-nitroaryl iodide and α-acetamidoacrylate or methyl acrylate.