35338-72-8Relevant academic research and scientific papers
Convenient, mild catalytic deprotection of oximes to carbonyl compounds with hydrogen peroxide and iodine catalyst in aqueous acetonitrile
Ganguly, Nemai C.,Nayek, Subhasis,Barik, Sujoy Kumar
experimental part, p. 4053 - 4061 (2009/12/24)
A clean, mild, and efficient catalytic deoximation procedure compatible with several common functional groups has been developed using 30% hydrogen peroxide activated by iodine catalyst in aqueous acetonitrile under essentially neutral conditions. The mechanistic features of an iodonium ion-driven nucleophilic cleavage of oximic C=N have been revealed.
A facile, catalytic deoximation method using potassium bromide and ammonium heptamolybdate in the presence of hydrogen peroxide in an aqueous medium
Ganguly, Nemai C.,Barik, Sujoy Kumar
, p. 425 - 428 (2008/09/20)
A simple, mild and efficient procedure for the cleavage of a wide range of ketoximes and aldoximes to the corresponding carbonyl compounds in an aqueous medium using catalytic amounts of potassium bromide and ammonium heptamolybdate tetrahydrate in combination with 30% hydrogen peroxide is described. Georg Thieme Verlag Stuttgart.
4,5-DIHYDRONAPHTHO [1,2-b] THIOPHENE DERIVATIVE
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Page/Page column 15, (2010/11/08)
A 4,5-dihydronaphtho[1,2-b]thiophene derivative expressed by the formula: (wherein R1 is a C1 to C10 1-hydroxyalkyl group or a C1 to C10 acyl group, and R2 and R3 separately substitute in the 6-, 7-, 8-, or 9-positions, and are each independently a hydrogen atom, a halogen atom, a C1 to C10 alkyl group, a hydroxy group, a C1 to C10 alkoxy group, a C1 to C5 alkenyloxy group, a C1 to C5 alkynyloxy group, a benzyloxy group, or the like, provided that when R1 is an acyl group and R2 is a hydrogen atom, then R3 is neither a hydrogen atom nor an acetyl group), or a pharmaceutically acceptable salt thereof. This is a novel compound that is effective in reducing triglyceride levels in the liver and reducing blood glucose levels.
Phosphonic acid compounds, their production and use
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, (2008/06/13)
The present invention relates to a compound of the general formula (I): STR1 wherein ring A is a benzene ring that may be substituted; Y is a divalent group as a constituent member of ring B forming a 5- to 8-membered ring; Q1 is a group of the formula --X--P(O)(OR1)(OR2) wherein X is a bond or a divalent group; R1 and R2, identical or different, are hydrogen or a lower alkyl, or may be combined together to form a ring; Q2 is hydrogen, a hydrocarbon group that may be substituted or a heterocyclic group that may be substituted; and the group of the formula --CON(Q1)(Q2) is connected to the a- or b-position carbon atom, or a salt thereof, which is useful as prophylactic and therapeutic agents of various metabolic bone diseases such as osteoporosis.
Ene-Ene-Retroene Conversion of (-)-β-Pinene to (+)-β-Selinene
Moore, Lionel,Gooding, David,Wolinsky, Joseph
, p. 3750 - 3754 (2007/10/02)
(-)-β-Pinene undergoes an ene reaction with acryloyl chloride at 70 deg C to afford 6,6-dimethylbicyclohept-2-ene-2-butanoyl chloride (2) in better than 80percent yield.Cyclization of 2 to 10,10-dimethyltricyclo2,7>undec-2(7)-en-6-one (4) by way of an intramolecular ene reaction involving a ketene intermediate occurs on heating with tributylamine at 150 deg C.Unsaturated ketone 4 undergoes a clean retroene reaction to yield (+)-7-(2-propenyl)-Δ9-decal-1-one (11) on brief heating at 265 deg C.Lithium dimethylcuprate addition to 11 yields a mixture of four isomeric 7-(2-propenyl)-10-methyl-1-decalones (15-18) where the isomers having the desired cis relationship between the angular methyl and the 2-propenyl groups comprise ca. 75percent of the product.Treatment of the ketone mixture with methylenetriphenylphosphorane completes the synthesis of (+)-β-selinene.
