35427-68-0

Usage

Salt Data

FREE

Usage

Reagent in organic synthesis

Application

Preparation of sulfonamide derivatives

Physical State

Colorless liquid

Odor

Strong, pungent

Chemical Reactions

Undergoes a range of chemical reactions

Industries

Used in pharmaceuticals, agriculture, and materials science

Source

Effective source of chloroalkylating agents

Reactivity

High reactivity with nucleophiles

Safety Precautions

Handle with caution

Health Risk

Hazardous to human health

Environmental Risk

Hazardous to the environment

Ventilation

Should be used in well-ventilated areas

Safety Measures

Appropriate safety measures should be taken during handling

Upstream product

• 3518-65-8 monochloromethanesulfonyl chloride 
• 124-40-3 dimethyl amine 

Downstream Products

• 861640-78-0 (3-([(dimethylamino)sulfonyl]methyl)-2-nitro-5,10,15,20-tetraphenylporphyrinato)zinc(II) 
• 473530-12-0 N,N-dimethyl-C-(5-phenyl-1,2,4-triazine)-methanesulphonamide 
• 130008-15-0 1,2-bis(N,N-dimethylsulfamoyl)-1,1a,1b,2-tetrahydro-1a-phenylbisazirino<1,2-a:2',1'-c>quinoxaline 
• 110380-88-6 (2R,3R)-3-Phenyl-oxirane-2-sulfonic acid dimethylamide 

Relevant academic research and scientific papers

Process for producing piperazinesulfonamide derivatives and salts thereof

A process for advantageously preparing a piperazinesulfonamide derivative represented by the general formula (III): wherein R1 is hydrogen atom, a straight or branched chain alkyl group having 1 to 6 carbon atoms, an alkoxy group having 1 to 4 carbon atoms, a halogen atom, hydroxyl group, trifluoromethyl group, nitro group or amino group; R2 is a phenyl group which may have as substituents on its phenyl ring 1 to 3 groups selected from the group consisting of an alkyl group having 1 to 4 carbon atoms, an alkoxy group having 1 to 4 carbon atoms, a halogen atom, hydroxyl group, trifluoromethyl group, nitro group and amino group, 2-pyridyl group, 3-pyridyl group or 4-pyridyl group; each of R3 and R4 is independently hydrogen atom, a straight or branched chain alkyl group having 1 to 6 carbon atoms, a hydroxyalkyl group having 1 to 4 carbon atoms, a cycloalkyl group having 3 to 8 carbon atoms, or a phenyl group which may be substituted; and Y is an alkylene group having 1 to 12 carbon atoms, and a salt thereof.

New antifilarial agents. 1. Epoxy sulfonamides and ethynesulfonamides

Two series of 2-substituted 1,2-epoxyethanesulfonamides 2 and ethynesulfonamides 5 were synthesized and evaluated for their antifilarial activity. The trans epoxides 2T were stereospecifically prepared by a Darzens reaction between aldehydes and halomethanesulfonamides. The cis isomers 2c were obtained from ethynesulfonamides 5 by semihydrogenation followed by KOCl epoxidation. 2-Substituted ethynesulfonamides 5 were synthesized from appropriate trans-ethenesulfonamides by a bromination/dehydrobromination sequence. These products, as well as several synthetic intermediates, were evaluated for antifilarial activity against Molinemia dessetae either in vivo in its natural host, the rodent Proechimys oris, or in vitro by a new test using cultures of the infective larvae. Most of the epoxides 2T and acetylenic derivatives 5 bearing a 2-aryl substituent were active in vitro. Among these compounds, four epoxides 2T and one acetylenic derivative 5 showed marked macrofilaricidal activity in vivo without any microfilaricidal activity. The differences between the in vivo and in vitro results may be due, in part, to the low chemical stability of the epoxy sulfonamides 2T. Despite this limitation, the activities observed in this reliable animal model suggest further development and testing of both series 2T and 5 as macrofilaricides.