35454-04-7Relevant articles and documents
Practical synthesis of functionalized 1,5-disubstituted 1,2,4-triazole derivatives
Xu, Yingju,McLaughlin, Mark,Bolton, Emily N.,Reamer, Robert A.
supporting information; experimental part, p. 8666 - 8669 (2011/02/28)
A general approach for the synthesis of 1,5-disubstituted-1,2,4-triazole compounds is described. A series of new oxamide-derived amidine reagents can be accessed in excellent yield with minimal purification necessary. Typically, these amidine reagents are stable crystalline solids and in certain cases were found to exist in a cyclic form as determined by NMR spectroscopy. Under optimized conditions, the direct reaction of these prepared reagents with various hydrazine hydrochloride salts efficiently generates the target triazoles. Both aromatic and aliphatic hydrazines react readily with the amidine reagents under very mild reaction conditions, delivering desired 1,5-disubstituted-1,2,4-triazole derivatives in good yields.
Modulators of Protein Tyrosine Phosphatases (PTPases)
-
, (2008/06/13)
The present invention provides novel thienopyridines, novel compositions, methods of their use, and methods of their manufacture, where such compounds of Formula 1 are pharmacologically useful inhibitors of Protein Tyrosine Phosphatases (PTPase's) includi
