35480-31-0

Usage

Uses

Used in Pharmaceutical Industry:
METHYL 2,5-BIS(2,2,2-TRIFLUOROETHOXY)BENZOATE is used as a key intermediate in the synthesis of Flecainide-d4, an isotope labeled analog of the antiarrhythmic drug Flecainide. METHYL 2,5-BIS(2,2,2-TRIFLUOROETHOXY)BENZOATE plays a crucial role in the development and production of Flecainide-d4, which is utilized for research purposes in understanding the mechanism of action and pharmacokinetics of Flecainide.

InChI:InChI=1/C12H10F6O4/c1-20-10(19)8-4-7(21-5-11(13,14)15)2-3-9(8)22-6-12(16,17)18/h2-4H,5-6H2,1H3

Upstream product

• 27831-94-3 N-((4-nitrophenyl)sulfonyl)benzamide 
• 353-83-3 1,1,1-trifluoro-2-iodoethane 
• 35480-46-7 2-(2,2,2-Trifluoroethoxy)benzoic acid 
• 98-88-4 benzoyl chloride 
• 67-56-1 methanol 
• 35480-52-5 2,5-di-(2,2,2-trifluoroethoxy)benzoic acid 

Downstream Products

• 50778-75-1 2,5-di-(2,2,2-trifluoroethoxy)benzoic acid hydrazide 
• 50778-59-1 2,5-bis(2,2,2-trifluoroethoxy)benzoic acid chloride 
• 35480-52-5 2,5-di-(2,2,2-trifluoroethoxy)benzoic acid 
• 54143-55-4 flecainide 

Relevant academic research and scientific papers

Synthesis of novel 5-(2,5-bis(2,2,2-trifluoroethoxy)phenyl)-1,3,4-oxadiazole-2-thiol derivatives as potential glucosidase inhibitors

Background: A hybrid molecule of different biologically active substances can improve affinity and efficiency compared to a standard drug. Hence based on this fact, we predict that a combination of fluorine, oxadiazole, sulfur, etc., may enhance α-glucosi

Palladium-Catalyzed C-H Trifluoroethoxylation of N-Sulfonylbenzamides

The trifluoroethyl aryl ethers are important motifs in drug molecules. However, a report devoted specifically to the study of transition-metal-catalyzed C-H trifluoroethoxylation has not been reported to date. A protocol of Pd(II)-catalyzed o-C-H trifluor

Novel process for the preparation of flecainide, its pharmaceutically acceptable salts and important intermediates thereof

Process for the preparation of Flecainide, its pharmaceutically acceptable salts and important intermediates thereof that involves the use of the 2-halobenzoic acid and its derivatives as a starting material. The use of this process also allows for the synthesis of a novel intermediate useful in the production of Flecainide. This new process is an inexpensive and efficient process for the manufacture of these compounds.