35495-11-5

Basic information

• Product Name: Z,Z-DIENESTROL
• Synonyms: (z,z)-dienestrol;4,4’-(1,2-diethylidene-1,2-ethanediyl)bis-,(z,z)-pheno;beta-dienestrol;cis,cis-dienestrol;isodienestrol;(Z,Z)-Dienoestrol;4,4'-[(1Z,2Z)-1,2-Diethylidene-1,2-ethanediyl]bisphenol;4,4'-[(2Z,4Z)-2,4-Hexadiene-3,4-diyl]bisphenol
• CAS NO: 35495-11-5
• Molecular Formula: C₁₈H₁₈O₂
• Molecular Weight: 266.338
• Product Categories: Aromatics Compounds;Aromatics;Metabolites;Intermediates & Fine Chemicals;Metabolites & Impurities;Pharmaceuticals
• Mol File: 35495-11-5.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 395.4°Cat760mmHg
• Flash Point: 181.4°C
• Appearance: White Solid
• Density: 1.129g/cm³
• Storage Temp.: Amber Vial, -20°C Freezer, Under Inert Atmosphere
• Solubility: DMSO (Slightly), Methanol (Slightly)
• Stability: Light Sensitive
• CAS DataBase Reference: Z,Z-DIENESTROL(CAS DataBase Reference)
• NIST Chemistry Reference: Z,Z-DIENESTROL(35495-11-5)
• EPA Substance Registry System: Z,Z-DIENESTROL(35495-11-5)

Safety Data

• Hazardous Substances Data: 35495-11-5(Hazardous Substances Data)

Usage

Chemical Properties

White Solid

Upstream product

• 56-53-1 diethylstilbestrol 
• 546-67-8 lead(IV) tetraacetate 
• 141-78-6 ethyl acetate 
• 71-43-2 benzene 
• 70244-13-2 4,4'-((2E,4E)-hexa-2,4-diene-3,4-diyl)bis(methoxybenzene) 
• 2749-94-2 1-methoxy-4-(prop-1-yn-1-yl)benzene 
• 112534-59-5 4-(2-chloro-propenyl)-anisole 
• 103505-40-4 4-(1,2-dichloro-propyl)-anisole 
• 1201-60-1 1-(1,2-dibromopropyl)-4-methoxybenzene 
• 24705-61-1 3,4-bis-(4-acetoxy-phenyl)-hexa-2t,4t-diene 
• 24705-62-2 Acetic acid 4-[(Z)-2-(4-acetoxy-phenyl)-1-eth-(Z)-ylidene-but-2-enyl]-phenyl ester 
• 4180-23-8 E-1-(4'-methoxyphenyl)prop-1-ene 
• 13029-44-2 dienestrol 
• 122-84-9 4-methoxybenzyl methyl ketone 

Downstream Products

• 24643-97-8 indenestrol A 
• 84-16-2 hexestrol 
• 84-16-2 dl-hexestrol 
• 106424-30-0 Dienoestrol-bis-β-(p-methoxyphenyl)-propionat 
• 106385-17-5 Dienoestrol-bis-β-(p-propoxyphenyl)-propionat 
• 106990-85-6 Dienoestrol-bis-β-(p-butoxyphenyl)-propionat 
• 106570-84-7 Dienoestrol-bis-β-(p-octoxyphenyl)-propionat 
• 38028-27-2 1-ethyl-2-(4-hydroxyphenyl)-3-methylinden-5-ol 
• 1071632-88-6 3-ethyl-1-methyl-6-propionyloxy-2-(4-propionyloxy-phenyl)-indene 
• 71855-45-3 indanestrol 
• 38028-29-4 5-acetoxy-2-(4-acetoxy-phenyl)-1-ethyl-3-methyl-indene 
• 84-19-5 dienoestrol diacetate 
• 115217-04-4 [3H]-(-)-Indenestrol A 
• 115217-03-3 [3H]-(+)-Indenestrol A 

Relevant articles and documents

Carbon-13 nuclear magnetic resonance study of meso-hexestrol and its derivatives

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NON-ESTROGENIC METABOLITES OF DIETHYLSTILBESTROL PRODUCED BY PROSTAGLANDIN SYNTHASE MEDIATED METABOLISM

Incubation of trans-diethylstilbestrol (E-DES) with prostaglandin synthase (PGS) in vitro leads to the formation of the metabolites cis,cis-dienestrol (Z,Z-DIES) and cis-diethylstilbestrol (Z-DES) which have considerably decreased estrogenic activity compared to their parent compound.Incubations of (14C)-E-DES with PGS in the presence of arachidonic acid (AA) predominantly catalyze formation of the oxidative metabolite Z,Z-DIES, accompanied by the formation of protein bound radioactivity.Inhibition of peroxidative metabolism through addition of indomethacin or absence of AA favors isomerization of E-DES to Z-DES without concomitant formation of protein bound radioactivity.Isomerization is inhibited by phenidone (1-phenyl-3-pyrazolidone).Since PGS activity is present in uterine tissue, these pathways may play a role in the metabolism of DES in its target tissue.