13029-44-2

Basic information

• Product Name: DIENESTROL
• Synonyms: 3 4-BIS(P-HYDROXYPHENYL)-2 4-HEXADIENE;3,4-BIS(4-HYDROXYPHENYL)-2,4-HEXADIENE;4,4'-DIHYDROXY-GAMMA,DELTA-DIPHENYL-BETA,DELTA-HEXADIENE;4,4'-(DIETHYLIDENEETHYLENE)DIPHENOL;3,4-DI(P-OXYPHENYL)-2 4-HEXADIENE;DIENESTROL,USP;4,4'-[(1E,2E)-1,2-Diethylidene-1,2-ethanediyl]bis-phenol;(e,e)-dienestrol
• CAS NO: 13029-44-2
• Molecular Formula: C₁₈H₁₈O₂
• Molecular Weight: 266.33
• EINECS: 201-519-7
• Product Categories: Aromatics Compounds;Aromatics;Metabolites;Intermediates & Fine Chemicals;Metabolites & Impurities;Pharmaceuticals
• Mol File: 13029-44-2.mol
• Article Data: 1

Chemical Properties

• Melting Point: 224-226°C
• Boiling Point: 349.54°C (rough estimate)
• Flash Point: 181.4°C
• Appearance: /
• Density: 1.1305 (rough estimate)
• Vapor Pressure: 8.07E-07mmHg at 25°C
• Refractive Index: 1.4800 (estimate)
• Storage Temp.: Amber Vial, -20°C Freezer, Under Inert Atmosphere
• Solubility: DMSO (Slightly), Methanol (Slightly)
• PKA: 10.18±0.15(Predicted)
• CAS DataBase Reference: DIENESTROL(CAS DataBase Reference)
• NIST Chemistry Reference: DIENESTROL(13029-44-2)
• EPA Substance Registry System: DIENESTROL(13029-44-2)

Safety Data

• Hazard Codes: Xn
• Statements: 40-48
• Safety Statements: 22-24/25
• WGK Germany: 3
• RTECS: SL0580000
• Hazardous Substances Data: 13029-44-2(Hazardous Substances Data)

Usage

Chemical Properties

Off-White Solid

Uses

Different sources of media describe the Uses of 13029-44-2 differently. You can refer to the following data:
1. A metabolite of Diethylstilbestrol
2. A metabolite of Diethylstilbestrol.

InChI:InChI=1/C18H18O2/c1-3-17(13-5-9-15(19)10-6-13)18(4-2)14-7-11-16(20)12-8-14/h3-12,19-20H,1-2H3/b17-3-,18-4-

Upstream product

• 121-97-1 4-Methoxypropiophenone 
• 70244-13-2 4,4'-((2E,4E)-hexa-2,4-diene-3,4-diyl)bis(methoxybenzene) 
• 1201-60-1 1-(1,2-dibromopropyl)-4-methoxybenzene 
• 103505-40-4 4-(1,2-dichloro-propyl)-anisole 
• 112534-59-5 4-(2-chloro-propenyl)-anisole 
• 122-84-9 4-methoxybenzyl methyl ketone 
• 70-70-2 4-hydroxypropiophenone 
• 18978-24-0 meso-3,4-bis-(4-hydroxy-phenyl)-hexane-3,4-diol 
• 2749-94-2 1-methoxy-4-(prop-1-yn-1-yl)benzene 
• 10035-10-6 hydrogen bromide 
• 71-43-2 benzene 
• 6209-24-1 3.4-bis-(4-benzoyloxy-phenyl)-hexadiene-(2t.4t) 
• 24705-61-1 3,4-bis-(4-acetoxy-phenyl)-hexa-2t,4t-diene 
• 56-53-1 diethylstilbestrol 

Downstream Products

• 115653-81-1 dienestrol monomethyl ether 
• 64490-51-3 4,5-bis-(4-hydroxy-phenyl)-3c,6c-dimethyl-cyclohex-4-ene-1r,2c-dicarboxylic acid-anhydride 
• 24643-97-8 indenestrol A 
• 84-16-2 hexestrol 
• 84-16-2 dl-hexestrol 
• 101606-38-6 optically inactive 2,5-dichloro-3,4-bis-(3,5-dibromo-4-hydroxy-phenyl)-hex-3t-ene 
• 107522-91-8 optically inactive 2,5-dibromo-3,4-bis-(3,5-dibromo-4-hydroxy-phenyl)-hex-3t-ene 
• 6209-24-1 3.4-bis-(4-benzoyloxy-phenyl)-hexadiene-(2t.4t) 
• 62899-48-3 Bis-(2-chloro-ethyl)-carbamic acid 4-[(E)-2-{4-[bis-(2-chloro-ethyl)-carbamoyloxy]-phenyl}-1-eth-(Z)-ylidene-but-2-enyl]-phenyl ester 
• 106424-30-0 Dienoestrol-bis-β-(p-methoxyphenyl)-propionat 
• 106385-17-5 Dienoestrol-bis-β-(p-propoxyphenyl)-propionat 
• 106990-85-6 Dienoestrol-bis-β-(p-butoxyphenyl)-propionat 
• 106570-84-7 Dienoestrol-bis-β-(p-octoxyphenyl)-propionat 
• 38028-27-2 1-ethyl-2-(4-hydroxyphenyl)-3-methylinden-5-ol 

Related news

Drag StandardsDetermination of DIENESTROL (cas 13029-44-2) in Pharmaceuticals09/10/2019

A polarographic method and an ultraviolet irradiation method for the determination of dienestrol in pharmaceuticals are presented. Both methods are capable of producing results of a higher degree of accuracy and precision than those obtainable by the U.S.P. XVI method.detailed

Research ArticlesAnalysis of DIENESTROL (cas 13029-44-2) and Its Dosage Forms by High-Performance Liquid Chromatography09/08/2019

A high-performance liquid chromatographic (HPLC) analysis is described for dienestrol as a drug substance and in cream, foam, and tablet dosage forms. After incorporation of the drug or dosage form into a solvent mixture containing an internal standard, biphenyl, an aliquot was chromatographed u...detailed

Research ArticlesGas-Liquid Chromatographic Determination of DIENESTROL (cas 13029-44-2) in the Presence of Methyltestosterone09/07/2019

A gas chromatographic procedure has been developed for the determination of dienestrol in the presence of methyltestosterone. Dienestrol was extracted from tablets and quantitatively determined by gas chromatography of its bis-(trimethylsilyl)ether. The bis-(trimethylsilyl)ether of alizarin was ...detailed

Drug StandardsInclusion Compounds in Pharmaceutical Analysis I: Determination of DIENESTROL (cas 13029-44-2) in DIENESTROL (cas 13029-44-2) Cream09/06/2019

Large ratios of monostearin to dienestrol in cream formulations complicate the development of an assay for dienestrol. Monostearin was removed easily in a test-tube procedure by channel-type inclusion in urea. Dienestrol recovery was complete and reproducible analyses were obtained by polarograp...detailed

Preparation and characterization of magnetic molecularly imprinted polymers for selective trace extraction of DIENESTROL (cas 13029-44-2) in seawater09/03/2019

Highly selective and efficient magnetic molecularly imprinted polymers (MMIPs) were prepared using Fe3O4@SiO2 as a magnetic supporter, 3-methacryloxypropyltrimethoxy-silane (MPS) as a silane coupling agent, DIS as a template, methacrylic acid (MAA) as a functional monomer and ethyleneglycol dime...detailed

Oral exposure of rats to DIENESTROL (cas 13029-44-2) during gestation and lactation: Effects on the reproductive system of male offspring09/02/2019

This study was aimed at determining whether dienestrol (DIES) affects reproduction in male offspring of rats following oral maternal exposure during gestation and lactation. Pregnant rats were treated from GD 6 to PND 21. Animals received 0 (control-vehicle), 0.75, 1.5, 3.12, 6.25, 12.5, 50, 75 ...detailed

Relevant articles and documents

Stereoselective Synthesis of Trisubstituted Vinylboronates from Ketone Enolates Triggered by 1,3-Metalate Rearrangement of Lithium Enolates

An unprecedented stereoselective synthesis of trisubstituted vinylboronates is reported to proceed by direct borylation of lithium ketone enolates under transition-metal-free conditions. The stereospecific C?O borylation of lithium enolates was triggered by a carbonyl-induced 1,3-metalate rearrangement via a C-bound boron enolate. DFT calculations and control experiments revealed that the stereoselectivity is controlled by sterics. A variety of stereospecific trisubstituted vinylboronates, together with several tetrasubstituted vinylboronates, were conveniently synthesized with the newly developed methodology. Based on the transformation of stereospecific vinylboronate, a single isomer of Dienestrol was efficiently obtained.