355-80-6

Usage

Uses

Used in Nanocrystal Synthesis:
2,2,3,3,4,4,5,5-Octafluoro-1-pentanol is used as a cosurfactant in the synthesis of silver and silver iodide nanocrystals. Its strong hydrogen bonding ability and high polarity make it an effective stabilizing agent for the formation of these nanocrystals.
Used in Semiconductor Industry:
2,2,3,3,4,4,5,5-Octafluoro-1-pentanol is used in the synthesis of Ag2S nanocrystals, which exhibit a characteristic surface plasmon resonance absorption at 330 nm. These nanocrystals have potential applications in optoelectronic devices, such as solar cells and photodetectors, due to their unique optical properties.

Safety Profile

Mildly toxic by inhalation. Whenheated to decomposition it emits toxic fumes of Fí. Seealso FLUORIDES and ALCOHOLS

InChI:InChI=1/C5H4F8O/c6-2(7)4(10,11)5(12,13)3(8,9)1-14/h2,14H,1H2

Upstream product

• 67-56-1 methanol 
• 116-14-3 polytetrafluoroethylene 
• 302-17-0 chloral hydrate 
• 87651-46-5 C₁₂H₁₁F₁₆O₂P 
• 111257-09-1 C₁₁H₉F₁₆O₂P 
• 2794-65-2 bis(1,1,5-octafluoropentyl) hydrogen phosphate 
• 71879-03-3 pentakis-(2,2,3,3,4,4,5,5-octafluoro-pentyloxy)-λ⁵-phosphane 
• 108-98-5 thiophenol 
• 80027-89-0 C₁₉H₁₉F₂₄NO₃S 
• 54822-22-9 methyl 2,2,3,3,4,4,5,5-octafluoropentanoate 
• 65611-17-8 tris(2,2,3,3,4,4,5,5-octafluoropentyl) phosphite 
• 1235819-13-2 (1,1,5-trihydrooctafluoropentyl) methylphosphinate 
• 2795-50-8 ethyl 5-Hperfluoropentanoate 
• 19932-27-5 2-(((2,2,3,3,4,4,5,5-octafluoropentyl)oxy)methyl)oxirane 

Downstream Products

• 308-36-1 Glutarsaeure-bis-(1H,1H,5H-octafluor-pentylester) 
• 376-94-3 3-Methyl-glutarsaeure-bis-<2,2,3,3,4,4,5,5-octafluor-pentylester> 
• 375-53-1 perfluoropentanal 
• 2794-65-2 bis(1,1,5-octafluoropentyl) hydrogen phosphate 
• 355-86-2 tris(2,2,3,3,4,4,5,5-octafluoropentyl) phosphate 
• 376-72-7 2,2,3,3,4,4,5,5-octafluorovaleric acid 
• 572-94-1 di(2,2,3,3,4,4,5,5-octafluoropent-1-yl) phthalate 
• 376-84-1 acrylate de trihydro-1,1,5 octafluoropentyle 
• 755-21-5 1-chloro-1H,1H,5H-perfluoropentane 
• 757-43-7 tetrakis-(2,2,3,3,4,4,5,5-octafluoro-pentyloxy)-methane 
• 4454-75-5 bis(2,2,3,3,4,4,5,5-octafluoropentyl) carbonate 
• 65064-81-5 1,1,2,2,3,3,4,4-Octafluoro-5-(1,1,2,3,3,3-hexafluoro-propoxy)-pentane 
• 16627-71-7 <1.1.2.2-Tetrafluor-aethyl>-<2.2.3.3.4.4.5.5-octafluor-pentyl>-aether 
• 1192-16-1 2,3-dihydrothiophene-1,1-dioxide 

Relevant academic research and scientific papers

Thermal desulfurization of (Alkoxymethyl)thiiranes

Reaction of (alkoxymethyl)oxiranes with thiourea in methanol has afforded the corresponding thiiranes, and catalyst-free thermal desulfurization of the products has been studied. The major products of desulfurization are alcohols and alkenes, both in the cases of (polyfluoroalkyloxymethyl)thiiranes and their non-fluorinated analogs. Longer alkyl chain in thiiranes favors formation of alcohols over alkenes formation in the course of desulfurization.

Incorporation of a 3-(2,2,2-Trifluoroethyl)-γ-hydroxy-γ-lactam motif in the side chain of 4-aminoquinolines. Syntheses and antimalarial activities

In this paper we report the synthesis and antimalarial properties of two series of fluoroalkylated γ-lactams derived from 4-aminoquinoline as potent chemotherapeutic agents for malaria treatment. These molecules obtained in several steps resulted in the identification of very potent structures with in vitro activity against Plasmodium falciparum clones of variable sensitivity (3D7 and W2) in the range of 19-50 nM with resistance indices in the range of 1.0-2.5. In addition, selected molecules (50, 51, 58, 60, 63, 70, 72, 74, 78, 81, 84, and 87) that are representative of the two series of compounds did not show cytotoxicity in vitro when tested against human umbilical vein endothelial cells up to a concentration of 100 μM. The most promising compounds (82 and 84) showed significant IC50 values close to 26 and 19 nM against the chloroquino-sensitive strain 3D7 and 49 and 42 nM against the multi-drug-resistant strain W2. Furthermore, two model compounds (50 and 70) were found to be quite stable over 48 h at pH 7.4 and 5.2. Overall, our preliminary data indicate that this class of structures contains promising candidates for further study.

Polyfluoroalloxy phosphonic and phosphinic acid derivatives: I. 1-Hydroxy-2,2,2-trichloroethylphosphinates

Polyfluoroalkyl esters of 1-hydroxy-2,2,2-trichloroethylphosphonic and aryl(alkyl-)phosphinic acids exhibited antienzyme activity towards esterases of animal and microbial origin. A good correlation is observed between high antiesterase activity of the target compounds and their physicochemical parameters, characterizing their structure.

Reduction of carbonyl compounds with polyethylsiloxane in the presence of titanium compounds

Reduction of carbonyl compounds with polyethylsiloxane in the presence of titanium alkoxides gives the corresponding alcohols in high yields.

PHOTOCHEMICAL SYNTHESIS OF FLUOROALKANOLS BASED ON TETRAFLUOROETHYLENE

The conditions of the photochemical synthesis of fluoroalkanols H(C2F4)nC(OH)R1R2 (n = 1, 2) by the reaction of tetrafluoroethylene with alcohols in the presence of photoinitiators and sensitisers are described.The reaction is initiated by UV radiation and is performed under atmospheric pressure.The yields of alkanols were 0.1-0.39 mol using 250 W UV lamp after 6-8 hours and 73-82 percent relatively to the converted tetrafluoroethylene.

(POLYFLUOROALKOXY)-N,N-DIALKYLAMINOFLUOROSULFURANES AND TRIS(POLYFLUOROALKOXY)-N,N-DIALKYLAMINOSULFURANES

(Polyfluoroalkoxy)-N,N-dialkylaminodifluorosulfuranes, bis(polyfluoroalkoxy)-N,N-dialkylaminofluorosulfuranes, and tris(polyfluoroalkoxy)-N,N-dialkylaminosulfuranes were obtained by the reaction of N,N-dialkylaminotrifluorosulfuranes with trimethylsilyloxypolyfluoroalkanes.