43138-64-3Relevant articles and documents
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Arnarp et al.
, p. C5 (1975)
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Oligosaccharides Self-Assemble and Show Intrinsic Optical Properties
Yu, Yang,Gim, Soeun,Kim, Dongyoon,Arnon, Zohar A.,Gazit, Ehud,Seeberger, Peter H.,Delbianco, Martina
supporting information, p. 4833 - 4838 (2019/03/26)
Self-assembling peptides and oligonucleotides have given rise to synthetic materials with several applications in nanotechnology. Aggregation of synthetic oligosaccharides into well-defined architectures has not been reported even though natural polysacch
Novel: O -methyl goniofufurone and 7- epi -goniofufurone derivatives: Synthesis, in vitro cytotoxicity and SAR analysis
Francuz, Jovana,Popsavin, Mirjana,Djoki?, Sanja,Koji?, Vesna,Srdi?-Raji?, Tatjana,Rodi?, Marko V.,Jakimov, Dimitar,Popsavin, Velimir
, p. 2017 - 2027 (2019/01/04)
Novel goniofufurone (1) and 7-epi-goniofufurone (2) derivatives bearing a methoxy group at the C-5 and/or C-7 positions were prepared and their in vitro antitumour activity against some human tumour cell lines was evaluated. Some of the analogues displayed powerful antiproliferative effects against the studied tumour cells, but almost all of them were non-cytotoxic toward the normal cells (MRC-5). A SAR study reveals that the introduction of a methoxy group at the C-7 position may increase the antiproliferative effects of the analogues. The most active compounds are 7-O-methyl derivatives of goniofufurone (3) and 7-epi-(+)-goniofufurone (6), which exhibited 1177- and 451-fold higher potencies than the leads 1 and 2 toward the MDA-MB 231 cell line. At the same time, compound 3 is almost 1.5-fold more active than the commercial drug doxorubicin (DOX) against the same cell line. Flow cytometry data confirmed that the cytotoxic effects of these analogues are mediated by apoptosis, additionally revealing that these molecules induced changes in the K562 cell cycle distribution.
Carbohydrate-based N-heterocyclic carbenes for enantioselective catalysis
Henderson, Alexander S.,Bower, John F.,Galan, M. Carmen
supporting information, p. 9180 - 9183 (2015/02/19)
Versatile syntheses of C2-linked and C2-symmetric carbohydrate-based imidazol(in)ium salts from functionalised amino-carbohydrate derivatives are reported. The novel NHCs were ligated to [Rh(COD)Cl]2 and evaluated in Rh-catalysed asymmetric hydrosilylation of ketones with good yields and promising enantioselectivities.