43138-64-3

Usage

Uses

Used in Pharmaceutical Industry:
(3R,4S)-3-[(4R)-2,2-dimethyl-1,3-dioxolan-4-yl]-4-methoxy-7,7-dimethyl-2,6,8-trioxabicyclo[3.3.0]octane is used as an active pharmaceutical ingredient for its anti-inflammatory, antipyretic, analgesic, and antispasmodic activities. Its ability to modulate various biological pathways makes it a promising candidate for the development of new drugs to treat various conditions, such as inflammation, pain, and muscle spasms.
Used in Cosmetic Industry:
In the cosmetic industry, (3R,4S)-3-[(4R)-2,2-dimethyl-1,3-dioxolan-4-yl]-4-methoxy-7,7-dimethyl-2,6,8-trioxabicyclo[3.3.0]octane can be used as an ingredient in anti-inflammatory and soothing products, such as creams, lotions, and serums. Its anti-inflammatory properties can help reduce redness and swelling, while its analgesic and antispasmodic activities can provide relief from pain and muscle tension.
Used in Nutraceutical Industry:
(3R,4S)-3-[(4R)-2,2-dimethyl-1,3-dioxolan-4-yl]-4-methoxy-7,7-dimethyl-2,6,8-trioxabicyclo[3.3.0]octane can also be utilized in the nutraceutical industry as a dietary supplement or functional food ingredient. Its various biological activities can contribute to overall health and well-being, supporting the body's natural inflammatory response and providing relief from occasional pain and discomfort.

InChI:InChI=1/C13H22O6/c1-12(2)15-6-7(17-12)8-9(14-5)10-11(16-8)19-13(3,4)18-10/h7-11H,6H2,1-5H3/t7-,8-,9+,10?,11?/m1/s1

Upstream product

• 582-52-5 1,2:5,6-di-O-isopropylidene-α-D-glucofuranose 
• 146-72-5 3-O-methyl-D-glucose 
• 67-64-1 acetone 
• 77-78-1 dimethyl sulfate 
• 74-88-4 methyl iodide 
• 64656-76-4 Natrium-Verbindung der O¹,O²;O⁵,O⁶-Diisopropyliden-α-D-glucofuranose 
• 1066-45-1 trimethyltin(IV)chloride 
• 79233-85-5 O-[1,2:5,6-di-O-isopropylidene-α-D-glucofuranosyl] 1H-imidazole-1-carbothioate 
• 14686-89-6 (1,2:5,6)-di-O-isopropylidene-D-gulose 
• 2595-05-3 Diacetone D-glucose 
• 2847-00-9 1,2:5,6-di-O-isopropylidene-α-D-hexofuran-3-ulose 
• 2280-44-6 D-Glucose 
• 50-99-7 D-glucose 
• 78730-56-0 1,2:5,6-di-O-isopropylidene-α-D-glucofuranose potassium salt 

Downstream Products

• 146-72-5 3-O-methyl-D-glucose 
• 18968-51-9 1,2-O-isopropylidene-3-O-methyl-α-D-xylo-pentodialdo-1,4-furanose 
• 3370-81-8 (3R,4R,5R,6R)-6-Hydroxymethyl-4-methoxy-tetrahydro-pyran-2,3,5-triol 
• 1338971-63-3 C₁₇H₂₄O₅ 
• 18968-51-9 1,2-O-isopropylidene-3-O-methyl-α-D-ribo-pentodialdo-1,4-furanose 
• 1391351-19-1 (R)-methyl 3-((3aR,5R,6R,6aR)-6-methoxy-2,2-dimethyltetrahydrofuro[2,3-d][1,3]-dioxol-5-yl)-3-((R)-2-methoxy-2-phenylacetamido)propanoate 
• 1391351-20-4 (R)-methyl 3-((3aR,5R,6R,6aR)-6-methoxy-2,2-dimethyltetrahydrofuro[2,3-d][1,3]-dioxol-5-yl)-3-((S)-2-methoxy-2-phenylacetamido)propanoate 
• 1391351-21-5 (S)-methyl 3-((3aR,5R,6R,6aR)-6-methoxy-2,2-dimethyltetrahydrofuro[2,3-d][1,3]-dioxol-5-yl)-3-((R)-2-methoxy-2-phenylacetamido)propanoate 
• 1391351-22-6 (S)-methyl 3-((3aR,5R,6R,6aR)-6-methoxy-2,2-dimethyltetrahydrofuro[2,3-d][1,3]-dioxol-5-yl)-3-((S)-2-methoxy-2-phenylacetamido)propanoate 
• 1391351-13-5 methyl (3R)-3-benzylamino-3-[6-methoxy-2,2-dimethyl-(3aR,6R,6aR)-perhydrofuro[2,3-d][1,3]dioxol-5-yl]propanoate 
• 1391351-14-6 methyl (3S)-3-benzylamino-3-[6-methoxy-2,2-dimethyl-(3aR,6R,6aR)-perhydrofuro[2,3-d][1,3]dioxol-5-yl]propanoate 
• 34383-11-4 5-O-benzyl-1,2-O-isopropylidene-3-O-methyl-α-D-xylofuranose 
• 35506-61-7 ((3aR,5R,6S,6aR)-6-Methoxy-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-5-yl)-methanol 
• 299184-00-2 (4aR,7R,8R,8aR)-6,8-Dimethoxy-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-7-ol 

Relevant academic research and scientific papers

THE CARBOHYDRATE MOIETIES BOUND TO THE CAROTENOIDS MYXOL AND OSCILLOL AND THEIR CHEMOSYSTEMATIC APPLICATIONS

Key Word Index - Oscillatoria agardhii; Carotenoid glycosides; myxol; oscillol; α-chivonosides; α-3-O-methylfucosides. The sugar moiety bound to myxol in Oscillatoria agardhii was shown by 1H NMR (400 MHz) experiments and glycoside hydrolysis to be α-linked chinovose, tentatively with L-configuration.Direct comparison of 100 MHz 1H NMR spectra of the acetates of myxol α-chinovoside and of oscilloxanthin ex Arthrospira sp. suggests the same sugar component in oscilloxanthin, and also in myxoxantophyll from the latter source.The O-methyl methylpentoside bound to myxol in O. bornetii f. tenuis was identified by 1H NMR as α-linked 3-O-methyl-fucose, tentatively L-configurated.The differentiation of species in the genus Oscillatoria, causing natural blooms in eutrophic lakes, was supported by their carotenoid pattern when including the differences in sugar moiety of the carotenoid glycosides.

Oligosaccharides Self-Assemble and Show Intrinsic Optical Properties

Self-assembling peptides and oligonucleotides have given rise to synthetic materials with several applications in nanotechnology. Aggregation of synthetic oligosaccharides into well-defined architectures has not been reported even though natural polysacch

Anti-coagulation pentasaccharide and preparing method and medical application thereof

The invention relates to a synthesized pentasaccharide compound, salt thereof, and application of the pentasaccharide compound in preparing medicines for preventing and/or treating blood coagulation disorder related diseases.

Novel: O -methyl goniofufurone and 7- epi -goniofufurone derivatives: Synthesis, in vitro cytotoxicity and SAR analysis

Novel goniofufurone (1) and 7-epi-goniofufurone (2) derivatives bearing a methoxy group at the C-5 and/or C-7 positions were prepared and their in vitro antitumour activity against some human tumour cell lines was evaluated. Some of the analogues displayed powerful antiproliferative effects against the studied tumour cells, but almost all of them were non-cytotoxic toward the normal cells (MRC-5). A SAR study reveals that the introduction of a methoxy group at the C-7 position may increase the antiproliferative effects of the analogues. The most active compounds are 7-O-methyl derivatives of goniofufurone (3) and 7-epi-(+)-goniofufurone (6), which exhibited 1177- and 451-fold higher potencies than the leads 1 and 2 toward the MDA-MB 231 cell line. At the same time, compound 3 is almost 1.5-fold more active than the commercial drug doxorubicin (DOX) against the same cell line. Flow cytometry data confirmed that the cytotoxic effects of these analogues are mediated by apoptosis, additionally revealing that these molecules induced changes in the K562 cell cycle distribution.

Furan glucosyl triazole type compound and preparation method and bactericide thereof

The invention relates to the field of bactericidal compounds, in particular to a furan glucosyl triazole type compound and a preparation and a bactericide thereof. The molecular formula of the furan glucosyl triazole type compound is shown in the following description, wherein R1 is methyl or benzyl, and R2 are phenyl and derivative of the phenyl or ethyl derivatives. Based on structural characteristics of the substrate fructose-6-phosphate and an ISOM catalytic hypothesis mechanism, the inventor adopts a five-membered furan glucose derivative with a similar structure as a basic skeleton, introduces an effective active group triazole structure of pesticides, designs a series of novel furan glucosyl triazole type compounds for the first time, studies the biological activities of the furan glucosyl triazole type compound, examines structure-activity relationships of the furan glucosyl triazole type compound, and lays the foundation for selecting better inhibitors.

Carbohydrate-based N-heterocyclic carbenes for enantioselective catalysis

Versatile syntheses of C2-linked and C2-symmetric carbohydrate-based imidazol(in)ium salts from functionalised amino-carbohydrate derivatives are reported. The novel NHCs were ligated to [Rh(COD)Cl]2 and evaluated in Rh-catalysed asymmetric hydrosilylation of ketones with good yields and promising enantioselectivities.

β-Oxygen effect in the Barton-McCombie deoxygenation reaction: Further experimental and theoretical findings

The chemistry of (S)-methyl xanthates derived from xylo- and ribo-furanose derivatives in the presence of the stannyl radical is investigated. Xanthate derived from β-xylo-furanose affords exclusively a deoxygenated product; whereas, under the same reacti

Design of β-amino acid with backbone-side chain interactions: Stabilization of 14/15-helix in α/β-peptides

A new C-linked carbo-β-amino acid, (R)-β-Caa(r), having a carbohydrate side chain with d-ribo configuration, was prepared from d-glucose by inverting the C-3 stereocenter to introduce constraints/ interactions. From the NMR studies it was inferred that the new monomer may participate in additional electrostatic interactions, facilitating and enhancing novel folds in oligomeric peptides derived from it. The α/β- peptides, synthesized from alternating l-Ala and (R)-β-Caa(r), have shown the presence of 14/15-helix by NMR (in CDCl3, methanol-d3 and CD3CN), CD and MD calculations. The hybrid peptides showed the presence of electrostatic interactions involving the intraresidue amide proton and the C3-OMe, which helped in the stabilization of the NH(i)???CO(i-4) H-bonds and adoption of 14/15-helix. The importance of such additional interactions has been well defined in recent times to stabilize the folding in a variety of peptidic foldamers. These observations suggest and emphasize that the side chain-backbone interactions are crucial in the stabilization of the desired folding propensity. The designed monomer thus enlarges the opportunities for the synthesis of peptides with novel conformations and expands the repertoire of the foldamers.

Synthesis and biological evaluation of sugar-derived chiral nitroimidazoles as potential antimycobacterial agents

Chiral nitroimidazoles were synthesized using sugars as the chiral source. The synthesized compounds showed promising antimycobacterial property with MIC value in the range 6.25-12.5 μg/mL against Mycobacterium tuberculosis H 37Rv.

Synthesis of locked pyranosyl nucleic acid (LpNA)

A new locked pyranosyl nucleoside was synthesized by phenylsulfinyl- assisted chemistry. The novel building block was inserted into oligonucleotides and provides new insight on conformational restricted pyranosyl nucleosides on duplex formation