15400-58-5

Basic information

• Product Name: METHYL 2,4-DIMETHOXYPYRIMIDINE-5-CARBOXYLATE
• Synonyms: METHYL 2,4-DIMETHOXYPYRIMIDINE-5-CARBOXYLATE;2,4-Dimethoxy-5-(methoxycarbonyl)pyrimidine, 2,4-Dimethoxy-5-(methoxycarbonyl)-1,3-diazine
• CAS NO: 15400-58-5
• Molecular Formula: C8H10N2O4
• Molecular Weight: 198.18
• Product Categories: Heterocycle-Pyrimidine series
• Mol File: 15400-58-5.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 327.808 °C at 760 mmHg
• Flash Point: 152.053 °C
• Appearance: /
• Density: 1.225 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.5
• CAS DataBase Reference: METHYL 2,4-DIMETHOXYPYRIMIDINE-5-CARBOXYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: METHYL 2,4-DIMETHOXYPYRIMIDINE-5-CARBOXYLATE(15400-58-5)
• EPA Substance Registry System: METHYL 2,4-DIMETHOXYPYRIMIDINE-5-CARBOXYLATE(15400-58-5)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 15400-58-5(Hazardous Substances Data)

Usage

General Description

Methyl 2,4-dimethoxypyrimidine-5-carboxylate is a chemical compound with the molecular formula C9H10N2O4. It is a pyrimidine derivative and belongs to the class of carboxylic acid esters. Methyl 2,4-dimethoxypyrimidine-5-carboxylate is commonly used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. Its properties make it suitable for use as a building block in the production of various functionalized pyrimidine derivatives. Methyl 2,4-dimethoxypyrimidine-5-carboxylate is also used in research and development laboratories for various organic chemistry applications.

InChI:InChI=1/C8H10N2O4/c1-12-6-5(7(11)13-2)4-9-8(10-6)14-3/h4H,1-3H3

Upstream product

• 186581-53-3 diazomethane 
• 3551-55-1 2,4-dimethoxypyrimidine 
• 124-38-9 carbon dioxide 
• 67-56-1 methanol 
• 110821-07-3 2,4-dimethoxypyrimidine-5-carboxylic acid 
• 62880-71-1 5-lithio-2,4-dimethoxypyrimidine 

Relevant articles and documents

AZABICYCLO [3. 1. O] HEXYL DERIVATIVES AS MODULATORS OF DOPAMINE D3 RECEPTORS

The present invention relates to novel compounds of formula (I) or a salt thereof: wherein R1 is a 5-membered heteroaryl group, optionally fused with a 6-membered hetero or carbocycle; such 5 or 11-membered system, may be optionally substituted by 1, 2, 3 or 4 substituents selected from the group consisting of: halogen, cyano, C1-4alkyl, haloC1-4alkyl, C1-4alkoxy, C1-4alkanoyl, haloC1-4alkoxy and SF5, and n is 1 or 2; processes for their preparation, intermediates used in these processes, pharmaceutical compositions containing them and their use in therapy, as modulators of dopamine D3 receptors, e.g. to treat drug dependency, as antipsychotic agents, to treat obsessive compulsive spectrum disorders, or premature ejaculation.

SYNTHESIS OF 5-SUBSTITUTED PYRIMIDINES THROUGH ortho-DIRECTED LITHIATION REACTIONS

Treatment of 2- and/or 4-substituted pyrimidine with LiTMP in ether at 0 deg C, followed by guenching with various electrophiles afforded the corresponding 5-substituted pyrimidines.