5151-34-8

Basic information

• Product Name: 2 4-DIMETHOXY-5-METHYLPYRIMIDINE 97
• Synonyms: 2 4-DIMETHOXY-5-METHYLPYRIMIDINE 97;2,4-Dimethoxy-5-methylpyridine;PyriMidine, 2,4-diMethoxy-5-Methyl-
• CAS NO: 5151-34-8
• Molecular Formula: C₇H₁₀N₂O₂
• Molecular Weight: 154.17
• Product Categories: Heterocyclic Compounds
• Mol File: 5151-34-8.mol
• Article Data: 6

Chemical Properties

• Melting Point: 58-62 °C(lit.)
• Appearance: /
• Storage Temp.: 2-8°C
• Sensitive: Air Sensitive
• CAS DataBase Reference: 2 4-DIMETHOXY-5-METHYLPYRIMIDINE 97(CAS DataBase Reference)
• NIST Chemistry Reference: 2 4-DIMETHOXY-5-METHYLPYRIMIDINE 97(5151-34-8)
• EPA Substance Registry System: 2 4-DIMETHOXY-5-METHYLPYRIMIDINE 97(5151-34-8)

Safety Data

• Hazard Codes: Xn
• Statements: 22-41-43
• Safety Statements: 37/39
• WGK Germany: 3
• Hazardous Substances Data: 5151-34-8(Hazardous Substances Data)

Usage

General Description

2,4-Dimethoxy-5-methylpyrimidine, usually acknowledged with 97% purity, is a specialized chemical compound characterized by a pyrimidine ring, a heterocyclic aromatic organic compound similar to benzene and pyridine. Pyrimidines comprise an essential class of organic compounds that facilitate as the building units in several significant polymers such as RNA and DNA. This particular derivative, 2,4-Dimethoxy-5-methylpyrimidine, is synthesized for various applications in fields like pharmaceuticals, biochemical research, and organic synthesis. The "97" refers to the approximate purity of the compound, indicating that it contains 97% of the specific 2,4-Dimethoxy-5-methylpyrimidine compound, which is important in maintaining the efficacy and reliability of scientific research and applications.

Upstream product

• 1780-31-0 2,6-dichloro-5-methylpyrimidine 
• 124-41-4 sodium methylate 
• 96606-05-2 5-methyl-6-chloro-2,4-dimethoxypyrimidine 
• 3551-55-1 2,4-dimethoxypyrimidine 
• 74-88-4 methyl iodide 
• 65-71-4 thymin 
• 7647-01-0 hydrogenchloride 
• 25902-89-0 4-methoxy-5-methyl-pyrimidin-2(1H)-one 
• 77-78-1 dimethyl sulfate 
• 56686-16-9 5-bromo-2,4-dimethoxypyrimidine 

Downstream Products

• 4160-72-9 1-methylthymine 
• 52606-02-7 2,4-dimethoxy-5-pyrimidine carboxaldehyde 
• 80955-99-3 1-(2-O-acetyl-3-deoxy-3-trifluoroacetamido-5-O-p-nitrobenzoyl-β-D-ribofuranosyl)-4-methoxy-5-methyl-1,2-dihydropyrimidin-2-one 
• 80504-45-6 1,2-dihydro-5-methyl-4-methoxy-2-oxo-1-(2'-benzoyloxyethoxymethyl)pyrimidine 
• 65-71-4 thymin 
• 25902-87-8 4-methoxy-1,5-dimethyl-2(1H)-pyrimidinone 
• 80504-53-6 5-methyl-1-(2'-O-p-tolylsulfonylethoxymethyl)uracil 
• 68724-11-8 1-[(2-hydroxyethoxy)methyl]thymine 
• 2140-61-6 5-methylcytidine 
• 7323-83-3 4-methoxy-5-methyl-1-(tri-O-benzoyl-β-D-ribofuranosyl)-1H-pyrimidin-2-one 

Relevant articles and documents

Deprotonative metalation of aromatic compounds by using an amino-based lithium cuprate

Deprotonative cupration of aromatic compounds by using amino-based lithium cuprates was optimized with 2,4-dimethoxypyrimidine and 2-methoxypyridine as the substrates and benzoyl chloride as the electrophile. [(tmp)2CuLi] (+2 LiCl) (tmp=2,2,6,6-tetramethylpiperidino) was identified as the best reagent and its use was extended to anisole, 1,4-dimethoxybenzene, other substituted pyridines, furan, thiophene and derivatives, and N-Boc-indole (Boc=tert-butyloxycarbonyl). Of the electrophiles employed to attempt the interception of the generated aryl cuprates, aroyl chlorides, iodomethane, and diphenyl disulfide efficiently reacted. In addition, different oxidative agents were identified to afford symmetrical biaryls. Finally, palladium-catalyzed coupling with aryl halides was optimized and allowed the synthesis of different aryl derivatives in medium to good yields.

Oxidative amination of cuprated pyrimidine and purine derivatives

Using regioselective cuprations (via magnesiations), various primary, secondary and tertiary aminated pyrimidine and purine derivatives were prepared by the oxidative coupling of lithium amidocuprates using chloranil. DNA and RNA units such as aminated uracil or thymine, and adenine, as well as a CDK inhibitor, purvalanol A, were all obtained under mild conditions and satisfactory yields.

Ortho-Directed Lithiation in ?-Deficient Diazinyl Heterocycles

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